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Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes.
Masters SL, Dunne A, Subramanian SL, Hull RL, Tannahill GM, Sharp FA, Becker C, Franchi L, Yoshihara E, Chen Z, Mullooly N, Mielke LA, Harris J, Coll RC, Mills KH, Mok KH, Newsholme P, Nuñez G, Yodoi J, Kahn SE, Lavelle EC, O'Neill LA. Masters SL, et al. Among authors: nunez g. Nat Immunol. 2010 Oct;11(10):897-904. doi: 10.1038/ni.1935. Epub 2010 Sep 12. Nat Immunol. 2010. PMID: 20835230 Free PMC article.
Sensing and reacting to microbes through the inflammasomes.
Franchi L, Muñoz-Planillo R, Núñez G. Franchi L, et al. Among authors: nunez g. Nat Immunol. 2012 Mar 19;13(4):325-32. doi: 10.1038/ni.2231. Nat Immunol. 2012. PMID: 22430785 Free PMC article. Review.
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.
Coll RC, Robertson AA, Chae JJ, Higgins SC, Muñoz-Planillo R, Inserra MC, Vetter I, Dungan LS, Monks BG, Stutz A, Croker DE, Butler MS, Haneklaus M, Sutton CE, Núñez G, Latz E, Kastner DL, Mills KH, Masters SL, Schroder K, Cooper MA, O'Neill LA. Coll RC, et al. Among authors: nunez g. Nat Med. 2015 Mar;21(3):248-55. doi: 10.1038/nm.3806. Epub 2015 Feb 16. Nat Med. 2015. PMID: 25686105 Free PMC article.
Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity.
Saunders SP, Moran T, Floudas A, Wurlod F, Kaszlikowska A, Salimi M, Quinn EM, Oliphant CJ, Núñez G, McManus R, Hams E, Irvine AD, McKenzie AN, Ogg GS, Fallon PG. Saunders SP, et al. Among authors: nunez g. J Allergy Clin Immunol. 2016 Feb;137(2):482-91. doi: 10.1016/j.jaci.2015.06.045. Epub 2015 Aug 20. J Allergy Clin Immunol. 2016. PMID: 26299987 Free PMC article.
Role of the microbiota in skin immunity and atopic dermatitis.
Yamazaki Y, Nakamura Y, Núñez G. Yamazaki Y, et al. Among authors: nunez g. Allergol Int. 2017 Oct;66(4):539-544. doi: 10.1016/j.alit.2017.08.004. Epub 2017 Sep 4. Allergol Int. 2017. PMID: 28882556 Free article. Review.
Staphylococcus Agr virulence is critical for epidermal colonization and associates with atopic dermatitis development.
Nakamura Y, Takahashi H, Takaya A, Inoue Y, Katayama Y, Kusuya Y, Shoji T, Takada S, Nakagawa S, Oguma R, Saito N, Ozawa N, Nakano T, Yamaide F, Dissanayake E, Suzuki S, Villaruz A, Varadarajan S, Matsumoto M, Kobayashi T, Kono M, Sato Y, Akiyama M, Otto M, Matsue H, Núñez G, Shimojo N. Nakamura Y, et al. Among authors: nunez g. Sci Transl Med. 2020 Jul 8;12(551):eaay4068. doi: 10.1126/scitranslmed.aay4068. Sci Transl Med. 2020. PMID: 32641488 Free PMC article.
592 results