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Selective inhibition of class IIa histone deacetylases alleviates renal fibrosis.
Xiong C, Guan Y, Zhou X, Liu L, Zhuang MA, Zhang W, Zhang Y, Masucci MV, Bayliss G, Zhao TC, Zhuang S. Xiong C, et al. Among authors: zhou x. FASEB J. 2019 Jul;33(7):8249-8262. doi: 10.1096/fj.201801067RR. Epub 2019 Apr 5. FASEB J. 2019. PMID: 30951378 Free PMC article.
Collectively, these results suggest that selectively targeting class IIa HDAC isoforms (in particular HDAC4) may inhibit development and progression of renal fibrosis by suppressing activation and expression of multiple profibrotic molecules and increasing expression of antifibro …
Collectively, these results suggest that selectively targeting class IIa HDAC isoforms (in particular HDAC4) may inhibit development and pro …
Targeting histone methyltransferase enhancer of zeste homolog-2 inhibits renal epithelial-mesenchymal transition and attenuates renal fibrosis.
Zhou X, Xiong C, Tolbert E, Zhao TC, Bayliss G, Zhuang S. Zhou X, et al. FASEB J. 2018 May 18;32(11):fj201800237R. doi: 10.1096/fj.201800237R. Online ahead of print. FASEB J. 2018. PMID: 29775417 Free PMC article.
These data indicate that EZH2 activation contributes to renal EMT and fibrosis through activation of multiple signaling pathways and suggest that EZH2 has potential as a therapeutic target for treatment of renal fibrosis.-Zhou, X., Xiong, C., Tolbert, E., Zhao, T. C …
These data indicate that EZH2 activation contributes to renal EMT and fibrosis through activation of multiple signaling pathways and suggest …
Blocking the histone lysine 79 methyltransferase DOT1L alleviates renal fibrosis through inhibition of renal fibroblast activation and epithelial-mesenchymal transition.
Liu L, Zou J, Guan Y, Zhang Y, Zhang W, Zhou X, Xiong C, Tolbert E, Zhao TC, Bayliss G, Zhuang S. Liu L, et al. Among authors: zhou x. FASEB J. 2019 Nov;33(11):11941-11958. doi: 10.1096/fj.201801861R. Epub 2019 Aug 2. FASEB J. 2019. PMID: 31373855 Free PMC article.
Thus, our data indicate that targeting DOT1L attenuates renal fibrosis through inhibition of renal fibroblasts and EMT by suppressing activation of multiple profibrotic signaling pathways while retaining expression of renoprotective factors.-Liu, L., Zou, J., Guan, Y., Zhang, Y., …
Thus, our data indicate that targeting DOT1L attenuates renal fibrosis through inhibition of renal fibroblasts and EMT by suppressing activa …
P2X7 receptor inhibition protects against ischemic acute kidney injury in mice.
Yan Y, Bai J, Zhou X, Tang J, Jiang C, Tolbert E, Bayliss G, Gong R, Zhao TC, Zhuang S. Yan Y, et al. Among authors: zhou x. Am J Physiol Cell Physiol. 2015 Mar 15;308(6):C463-72. doi: 10.1152/ajpcell.00245.2014. Epub 2015 Jan 14. Am J Physiol Cell Physiol. 2015. PMID: 25588875 Free PMC article.
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