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Mitochondrial DNA: A new driver for sex differences in spontaneous hypertension.
Echem C, Costa TJD, Oliveira V, Giglio Colli L, Landgraf MA, Rodrigues SF, Franco MDCP, Landgraf RG, Santos-Eichler RA, Bomfim GF, Akamine EH, de Carvalho MHC. Echem C, et al. Among authors: costa tjd. Pharmacol Res. 2019 Jun;144:142-150. doi: 10.1016/j.phrs.2019.04.008. Epub 2019 Apr 6. Pharmacol Res. 2019. PMID: 30965087
An interaction of renin-angiotensin and kallikrein-kinin systems contributes to vascular hypertrophy in angiotensin II-induced hypertension: in vivo and in vitro studies.
Ceravolo GS, Montezano AC, Jordão MT, Akamine EH, Costa TJ, Takano AP, Fernandes DC, Barreto-Chaves ML, Laurindo FR, Tostes RC, Fortes ZB, Chopard RP, Touyz RM, Carvalho MH. Ceravolo GS, et al. PLoS One. 2014 Nov 4;9(11):e111117. doi: 10.1371/journal.pone.0111117. eCollection 2014. PLoS One. 2014. PMID: 25369284 Free PMC article.
Association of testosterone with estrogen abolishes the beneficial effects of estrogen treatment by increasing ROS generation in aorta endothelial cells.
Costa TJ, Ceravolo GS, dos Santos RA, de Oliveira MA, Araújo PX, Giaquinto LR, Tostes RC, Akamine EH, Fortes ZB, Dantas AP, Carvalho MH. Costa TJ, et al. Am J Physiol Heart Circ Physiol. 2015 Apr 1;308(7):H723-32. doi: 10.1152/ajpheart.00681.2014. Epub 2015 Jan 30. Am J Physiol Heart Circ Physiol. 2015. PMID: 25637546 Free article.
Detrimental Effects of Testosterone Addition to Estrogen Therapy Involve Cytochrome P-450-Induced 20-HETE Synthesis in Aorta of Ovariectomized Spontaneously Hypertensive Rat (SHR), a Model of Postmenopausal Hypertension.
Costa TJ, Ceravolo GS, Echem C, Hashimoto CM, Costa BP, Santos-Eichler RA, Oliveira MA, Jiménez-Altayó F, Akamine EH, Dantas AP, Carvalho MHC. Costa TJ, et al. Front Physiol. 2018 May 8;9:490. doi: 10.3389/fphys.2018.00490. eCollection 2018. Front Physiol. 2018. PMID: 29867542 Free PMC article.
Mitochondrial DNA and TLR9 activation contribute to SARS-CoV-2-induced endothelial cell damage.
Costa TJ, Potje SR, Fraga-Silva TFC, da Silva-Neto JA, Barros PR, Rodrigues D, Machado MR, Martins RB, Santos-Eichler RA, Benatti MN, de Sá KSG, Almado CEL, Castro ÍA, Pontelli MC, Serra L, Carneiro FS, Becari C, Louzada-Junior P, Oliveira RDR, Zamboni DS, Arruda E, Auxiliadora-Martins M, Giachini FRC, Bonato VLD, Zachara NE, Bomfim GF, Tostes RC. Costa TJ, et al. Vascul Pharmacol. 2022 Feb;142:106946. doi: 10.1016/j.vph.2021.106946. Epub 2021 Nov 25. Vascul Pharmacol. 2022. PMID: 34838735 Free PMC article.
Carotid dysfunction in senescent female mice is mediated by increased α1A-adrenoceptor activity and COX-derived vasoconstrictor prostanoids.
Costa TJ, Barros PR, Duarte DA, Silva-Neto JA, Hott SC, Santos-Silva T, Costa-Neto CM, Gomes FV, Akamine EH, McCarthy CG, Jimenez-Altayó F, Dantas AP, Tostes RC. Costa TJ, et al. Am J Physiol Heart Circ Physiol. 2023 Apr 1;324(4):H417-H429. doi: 10.1152/ajpheart.00495.2022. Epub 2023 Jan 27. Am J Physiol Heart Circ Physiol. 2023. PMID: 36705993 Free article.
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