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Structure Overhaul Affords a Potent Purine PI3Kδ Inhibitor with Improved Tolerability.
Methot JL, Zhou H, Kattar SD, McGowan MA, Wilson K, Garcia Y, Deng Y, Altman M, Fradera X, Lesburg C, Fischmann T, Li C, Alves S, Shah S, Fernandez R, Goldenblatt P, Hill A, Shaffer L, Chen D, Tong V, McLeod RL, Yu H, Bass A, Kemper R, Gatto NT, LaFranco-Scheuch L, Trotter BW, Guzi T, Katz JD. Methot JL, et al. Among authors: fernandez r. J Med Chem. 2019 May 9;62(9):4370-4382. doi: 10.1021/acs.jmedchem.8b01818. Epub 2019 Apr 22. J Med Chem. 2019. PMID: 30986068
The Discovery of 3-((4-Chloro-3-methoxyphenyl)amino)-1-((3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl)-1H-pyrazole-4-carboxamide, a Highly Ligand Efficient and Efficacious Janus Kinase 1 Selective Inhibitor with Favorable Pharmacokinetic Properties.
Siu T, Brubaker J, Fuller P, Torres L, Zeng H, Close J, Mampreian DM, Shi F, Liu D, Fradera X, Johnson K, Bays N, Kadic E, He F, Goldenblatt P, Shaffer L, Patel SB, Lesburg CA, Alpert C, Dorosh L, Deshmukh SV, Yu H, Klappenbach J, Elwood F, Dinsmore CJ, Fernandez R, Moy L, Young JR. Siu T, et al. Among authors: fernandez r. J Med Chem. 2017 Dec 14;60(23):9676-9690. doi: 10.1021/acs.jmedchem.7b01135. Epub 2017 Dec 4. J Med Chem. 2017. PMID: 29156136
Curbing the major and growing threats from invasive alien species is urgent and achievable.
Roy HE, Pauchard A, Stoett PJ, Renard Truong T, Meyerson LA, Bacher S, Galil BS, Hulme PE, Ikeda T, Kavileveettil S, McGeoch MA, Nuñez MA, Ordonez A, Rahlao SJ, Schwindt E, Seebens H, Sheppard AW, Vandvik V, Aleksanyan A, Ansong M, August T, Blanchard R, Brugnoli E, Bukombe JK, Bwalya B, Byun C, Camacho-Cervantes M, Cassey P, Castillo ML, Courchamp F, Dehnen-Schmutz K, Zenni RD, Egawa C, Essl F, Fayvush G, Fernandez RD, Fernandez M, Foxcroft LC, Genovesi P, Groom QJ, González AI, Helm A, Herrera I, Hiremath AJ, Howard PL, Hui C, Ikegami M, Keskin E, Koyama A, Ksenofontov S, Lenzner B, Lipinskaya T, Lockwood JL, Mangwa DC, Martinou AF, McDermott SM, Morales CL, Müllerová J, Mungi NA, Munishi LK, Ojaveer H, Pagad SN, Pallewatta NPKTS, Peacock LR, Per E, Pergl J, Preda C, Pyšek P, Rai RK, Ricciardi A, Richardson DM, Riley S, Rono BJ, Ryan-Colton E, Saeedi H, Shrestha BB, Simberloff D, Tawake A, Tricarico E, Vanderhoeven S, Vicente J, Vilà M, Wanzala W, Werenkraut V, Weyl OLF, Wilson JRU, Xavier RO, Ziller SR. Roy HE, et al. Among authors: fernandez rd. Nat Ecol Evol. 2024 Jun 3. doi: 10.1038/s41559-024-02412-w. Online ahead of print. Nat Ecol Evol. 2024. PMID: 38831016 Review.
DEI infrastructures required for the best science and medicine.
Tornini VA, Fernandez RW, Goldman OV, Suarez J. Tornini VA, et al. Among authors: fernandez rw. Lancet. 2024 Jun 1;403(10442):2375. doi: 10.1016/S0140-6736(24)00697-4. Lancet. 2024. PMID: 38823984 No abstract available.
Azole resistance screening in Aspergillus fumigatus sensu stricto using the azole-containing agar method (EUCAST E.Def 10.2): conidial suspension filtration and inoculum adjustment before inoculum preparation may not be needed.
Serrano-Lobo J, Reigadas E, Muñoz P, Escribano P, Guinea J; ASPEIN Study Group. Serrano-Lobo J, et al. J Clin Microbiol. 2024 May 31:e0036924. doi: 10.1128/jcm.00369-24. Online ahead of print. J Clin Microbiol. 2024. PMID: 38819167
Fish oil supplementation in obese rats ameliorates metabolic syndrome response.
Freitas DMB, Oliveira BAC, Henschel LDV, Oliveira MHAPC, Zazula M, Horlem E, Rodriguez DFS, Carvalhal SRS, Iagher F, Fernandez R, Naliwaiko K, Fernandes LC. Freitas DMB, et al. Among authors: fernandez r. Braz J Med Biol Res. 2024 May 20;57:e13172. doi: 10.1590/1414-431X2024e13172. eCollection 2024. Braz J Med Biol Res. 2024. PMID: 38808884 Free PMC article.
Cost of controlling the dengue vector Aedes aegypti in the Peruvian amazon.
Durand S, Paredes A, Pacheco C, Fernandez R, Herrera J, Cabezas C. Durand S, et al. Among authors: fernandez r. Rev Peru Med Exp Salud Publica. 2024 May 27;41(1):46-53. doi: 10.17843/rpmesp.2024.411.12905. Rev Peru Med Exp Salud Publica. 2024. PMID: 38808844 English, Spanish.
Management of race, ethnicity, and language data in the pediatric emergency department.
Gutman CK, Hartford EA, Gifford S, Ford V, Bouvay K, Pickett ML, Tran TT, Molyneaux Slade ND, Piroutek MJ, Chung S, Roach B, Hincapie M, Hoffmann JA, Lin K, Kotler H, Pulcini C, Rose JA, Bergmann KR, Cheng T, St Pierre Hetz R, Yan X, Lou XY, Fernandez R, Aronson PL, Lion KC; Pediatric Emergency Medicine Collaborative Research Committee Febrile Infants and Health Disparities Study Group. Gutman CK, et al. Among authors: fernandez r. Acad Emerg Med. 2024 May 29. doi: 10.1111/acem.14947. Online ahead of print. Acad Emerg Med. 2024. PMID: 38808384 No abstract available.
2,664 results