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PD-1/PD-L1 Blockade Enhances T-cell Activity and Antitumor Efficacy of Imatinib in Gastrointestinal Stromal Tumors.
Seifert AM, Zeng S, Zhang JQ, Kim TS, Cohen NA, Beckman MJ, Medina BD, Maltbaek JH, Loo JK, Crawley MH, Rossi F, Besmer P, Antonescu CR, DeMatteo RP. Seifert AM, et al. Among authors: maltbaek jh. Clin Cancer Res. 2017 Jan 15;23(2):454-465. doi: 10.1158/1078-0432.CCR-16-1163. Epub 2016 Jul 28. Clin Cancer Res. 2017. PMID: 27470968 Free PMC article.
Macrophages and CD8+ T Cells Mediate the Antitumor Efficacy of Combined CD40 Ligation and Imatinib Therapy in Gastrointestinal Stromal Tumors.
Zhang JQ, Zeng S, Vitiello GA, Seifert AM, Medina BD, Beckman MJ, Loo JK, Santamaria-Barria J, Maltbaek JH, Param NJ, Moral JA, Zhao JN, Balachandran V, Rossi F, Antonescu CR, DeMatteo RP. Zhang JQ, et al. Among authors: maltbaek jh. Cancer Immunol Res. 2018 Apr;6(4):434-447. doi: 10.1158/2326-6066.CIR-17-0345. Epub 2018 Feb 21. Cancer Immunol Res. 2018. PMID: 29467128 Free PMC article.
Csf1r or Mer inhibition delays liver regeneration via suppression of Kupffer cells.
Santamaria-Barria JA, Zeng S, Greer JB, Beckman MJ, Seifert AM, Cohen NA, Zhang JQ, Crawley MH, Green BL, Loo JK, Maltbaek JH, DeMatteo RP. Santamaria-Barria JA, et al. Among authors: maltbaek jh. PLoS One. 2019 May 1;14(5):e0216275. doi: 10.1371/journal.pone.0216275. eCollection 2019. PLoS One. 2019. PMID: 31042769 Free PMC article.
The V654A second-site KIT mutation increases tumor oncogenesis and STAT activation in a mouse model of gastrointestinal stromal tumor.
Zhang JQ, Bosbach B, Loo JK, Vitiello GA, Zeng S, Seifert AM, Medina BD, Param NJ, Maltbaek JH, Rossi F, Antonescu CR, Besmer P, DeMatteo RP. Zhang JQ, et al. Among authors: maltbaek jh. Oncogene. 2020 Dec;39(49):7153-7165. doi: 10.1038/s41388-020-01489-4. Epub 2020 Oct 6. Oncogene. 2020. PMID: 33024275 Free PMC article.
Wnt/β-catenin Signaling Contributes to Tumor Malignancy and Is Targetable in Gastrointestinal Stromal Tumor.
Zeng S, Seifert AM, Zhang JQ, Cavnar MJ, Kim TS, Balachandran VP, Santamaria-Barria JA, Cohen NA, Beckman MJ, Medina BD, Rossi F, Crawley MH, Loo JK, Maltbaek JH, Besmer P, Antonescu CR, DeMatteo RP. Zeng S, et al. Among authors: maltbaek jh. Mol Cancer Ther. 2017 Sep;16(9):1954-1966. doi: 10.1158/1535-7163.MCT-17-0139. Epub 2017 Jun 13. Mol Cancer Ther. 2017. PMID: 28611108 Free PMC article.
Human DNA-PK activates a STING-independent DNA sensing pathway.
Burleigh K, Maltbaek JH, Cambier S, Green R, Gale M Jr, James RC, Stetson DB. Burleigh K, et al. Among authors: maltbaek jh. Sci Immunol. 2020 Jan 24;5(43):eaba4219. doi: 10.1126/sciimmunol.aba4219. Sci Immunol. 2020. PMID: 31980485 Free PMC article.