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Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M.
Christoffersen C, Obinata H, Kumaraswamy SB, Galvani S, Ahnström J, Sevvana M, Egerer-Sieber C, Muller YA, Hla T, Nielsen LB, Dahlbäck B. Christoffersen C, et al. Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9613-8. doi: 10.1073/pnas.1103187108. Epub 2011 May 23. Proc Natl Acad Sci U S A. 2011. PMID: 21606363 Free PMC article.
Sphingosine-1-phosphate reduces ischaemia-reperfusion injury by phosphorylating the gap junction protein Connexin43.
Morel S, Christoffersen C, Axelsen LN, Montecucco F, Rochemont V, Frias MA, Mach F, James RW, Naus CC, Chanson M, Lampe PD, Nielsen MS, Nielsen LB, Kwak BR. Morel S, et al. Among authors: christoffersen c. Cardiovasc Res. 2016 Mar 1;109(3):385-96. doi: 10.1093/cvr/cvw004. Epub 2016 Jan 13. Cardiovasc Res. 2016. PMID: 26762268 Free PMC article.
Impaired endothelial barrier function in apolipoprotein M-deficient mice is dependent on sphingosine-1-phosphate receptor 1.
Christensen PM, Liu CH, Swendeman SL, Obinata H, Qvortrup K, Nielsen LB, Hla T, Di Lorenzo A, Christoffersen C. Christensen PM, et al. Among authors: christoffersen c. FASEB J. 2016 Jun;30(6):2351-9. doi: 10.1096/fj.201500064. Epub 2016 Mar 8. FASEB J. 2016. PMID: 26956418 Free PMC article.
The study suggests that vascular leakage of albumin-sized particles in ApoM deficiency is S1P- and S1P1-dependent and this dependency exacerbates the response to inflammatory stimuli.-Christensen, P. M., Liu, C. H., Swendeman, S. L., Obinata, H., Qvortrup, K., Nielsen, L B …
The study suggests that vascular leakage of albumin-sized particles in ApoM deficiency is S1P- and S1P1-dependent and this dependency exacer …
Familial hypercholesterolaemia: cholesterol efflux and coronary disease.
Versmissen J, Vongpromek R, Yahya R, van der Net JB, van Vark-van der Zee L, Blommesteijn-Touw J, Wattimena D, Rietveld T, Pullinger CR, Christoffersen C, Dahlbäck B, Kane JP, Mulder M, Sijbrands EJ. Versmissen J, et al. Among authors: christoffersen c. Eur J Clin Invest. 2016 Jul;46(7):643-50. doi: 10.1111/eci.12643. Epub 2016 Jun 20. Eur J Clin Invest. 2016. PMID: 27208892 Free PMC article.
High density lipoprotein (HDL)-associated sphingosine 1-phosphate (S1P) inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression.
Feuerborn R, Becker S, Potì F, Nagel P, Brodde M, Schmidt H, Christoffersen C, Ceglarek U, Burkhardt R, Nofer JR. Feuerborn R, et al. Among authors: christoffersen c. Atherosclerosis. 2017 Feb;257:29-37. doi: 10.1016/j.atherosclerosis.2016.12.009. Epub 2016 Dec 9. Atherosclerosis. 2017. PMID: 28038379
184 results