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Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in Caenorhabditis elegans.
Huang C, Wagner-Valladolid S, Stephens AD, Jung R, Poudel C, Sinnige T, Lechler MC, Schlörit N, Lu M, Laine RF, Michel CH, Vendruscolo M, Kaminski CF, Kaminski Schierle GS, David DC. Huang C, et al. Among authors: vendruscolo m. Elife. 2019 May 3;8:e43059. doi: 10.7554/eLife.43059. Elife. 2019. PMID: 31050339 Free PMC article.
ALS mutations in FUS cause neuronal dysfunction and death in Caenorhabditis elegans by a dominant gain-of-function mechanism.
Murakami T, Yang SP, Xie L, Kawano T, Fu D, Mukai A, Bohm C, Chen F, Robertson J, Suzuki H, Tartaglia GG, Vendruscolo M, Kaminski Schierle GS, Chan FT, Moloney A, Crowther D, Kaminski CF, Zhen M, St George-Hyslop P. Murakami T, et al. Among authors: vendruscolo m. Hum Mol Genet. 2012 Jan 1;21(1):1-9. doi: 10.1093/hmg/ddr417. Epub 2011 Sep 23. Hum Mol Genet. 2012. PMID: 21949354 Free PMC article.
Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism.
Cohen SI, Linse S, Luheshi LM, Hellstrand E, White DA, Rajah L, Otzen DE, Vendruscolo M, Dobson CM, Knowles TP. Cohen SI, et al. Among authors: vendruscolo m. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9758-63. doi: 10.1073/pnas.1218402110. Epub 2013 May 23. Proc Natl Acad Sci U S A. 2013. PMID: 23703910 Free PMC article.
Widespread Proteome Remodeling and Aggregation in Aging C. elegans.
Walther DM, Kasturi P, Zheng M, Pinkert S, Vecchi G, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M, Mann M, Hartl FU. Walther DM, et al. Among authors: vendruscolo m. Cell. 2015 May 7;161(4):919-32. doi: 10.1016/j.cell.2015.03.032. Cell. 2015. PMID: 25957690 Free PMC article.
ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function.
Murakami T, Qamar S, Lin JQ, Schierle GS, Rees E, Miyashita A, Costa AR, Dodd RB, Chan FT, Michel CH, Kronenberg-Versteeg D, Li Y, Yang SP, Wakutani Y, Meadows W, Ferry RR, Dong L, Tartaglia GG, Favrin G, Lin WL, Dickson DW, Zhen M, Ron D, Schmitt-Ulms G, Fraser PE, Shneider NA, Holt C, Vendruscolo M, Kaminski CF, St George-Hyslop P. Murakami T, et al. Among authors: vendruscolo m. Neuron. 2015 Nov 18;88(4):678-90. doi: 10.1016/j.neuron.2015.10.030. Epub 2015 Oct 29. Neuron. 2015. PMID: 26526393 Free PMC article.
Structural basis of synaptic vesicle assembly promoted by α-synuclein.
Fusco G, Pape T, Stephens AD, Mahou P, Costa AR, Kaminski CF, Kaminski Schierle GS, Vendruscolo M, Veglia G, Dobson CM, De Simone A. Fusco G, et al. Among authors: vendruscolo m. Nat Commun. 2016 Sep 19;7:12563. doi: 10.1038/ncomms12563. Nat Commun. 2016. PMID: 27640673 Free PMC article.
522 results