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Design and Discovery of N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic.
Ramurthy S, Taft BR, Aversa RJ, Barsanti PA, Burger MT, Lou Y, Nishiguchi GA, Rico A, Setti L, Smith A, Subramanian S, Tamez V, Tanner H, Wan L, Hu C, Appleton BA, Mamo M, Tandeske L, Tellew JE, Huang S, Yue Q, Chaudhary A, Tian H, Iyer R, Hassan AQ, Mathews Griner LA, La Bonte LR, Cooke VG, Van Abbema A, Merritt H, Gampa K, Feng F, Yuan J, Mishina Y, Wang Y, Haling JR, Vaziri S, Hekmat-Nejad M, Polyakov V, Zang R, Sethuraman V, Amiri P, Singh M, Sellers WR, Lees E, Shao W, Dillon MP, Stuart DD. Ramurthy S, et al. Among authors: iyer r. J Med Chem. 2020 Mar 12;63(5):2013-2027. doi: 10.1021/acs.jmedchem.9b00161. Epub 2019 May 16. J Med Chem. 2020. PMID: 31059256
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma.
Bollag G, Hirth P, Tsai J, Zhang J, Ibrahim PN, Cho H, Spevak W, Zhang C, Zhang Y, Habets G, Burton EA, Wong B, Tsang G, West BL, Powell B, Shellooe R, Marimuthu A, Nguyen H, Zhang KY, Artis DR, Schlessinger J, Su F, Higgins B, Iyer R, D'Andrea K, Koehler A, Stumm M, Lin PS, Lee RJ, Grippo J, Puzanov I, Kim KB, Ribas A, McArthur GA, Sosman JA, Chapman PB, Flaherty KT, Xu X, Nathanson KL, Nolop K. Bollag G, et al. Among authors: iyer r. Nature. 2010 Sep 30;467(7315):596-9. doi: 10.1038/nature09454. Nature. 2010. PMID: 20823850 Free PMC article. Clinical Trial.
ACR Appropriateness Criteria® Urinary Tract Infection-Child: 2023 Update.
Expert Panel on Pediatric Imaging; Chandra T, Bajaj M, Iyer RS, Chan SS, Bardo DME, Chen J, Cooper ML, Kaplan SL, Levin TL, Moore MM, Peters CA, Saidinejad M, Schooler GR, Shet NS, Squires JH, Trout AT, Pruthi S. Expert Panel on Pediatric Imaging, et al. Among authors: iyer rs. J Am Coll Radiol. 2024 Jun;21(6S):S326-S342. doi: 10.1016/j.jacr.2024.02.025. J Am Coll Radiol. 2024. PMID: 38823954
ACR Appropriateness Criteria® Soft Tissue Vascular Anomalies: Vascular Malformations and Infantile Vascular Tumors (Non-CNS)-Child.
Expert Panel on Pediatric Imaging; Bardo DME, Gill AE, Iyer RS, Chan SS, Cooper ML, Dasgupta RA, Guimaraes CV, Hammer MR, Krowchuk DP, Levin TL, Liang MG, Meyers ML, Samet JD, Sammer MBK, Schooler GR, Squires JH, Sura AS, Trout AT, Pruthi S. Expert Panel on Pediatric Imaging, et al. Among authors: iyer rs. J Am Coll Radiol. 2024 Jun;21(6S):S310-S325. doi: 10.1016/j.jacr.2024.02.030. J Am Coll Radiol. 2024. PMID: 38823953
Wake Up Safe in the USA & International Patient Safety.
Iyer RS, Dave N, Du T, Bong CL, Siow YN, Taylor E, Tjia I. Iyer RS, et al. Paediatr Anaesth. 2024 May 29. doi: 10.1111/pan.14920. Online ahead of print. Paediatr Anaesth. 2024. PMID: 38808685 Review.
Models using comprehensive, lesion-level, longitudinal [68Ga]Ga-DOTA-TATE PET-derived features lead to superior outcome prediction in neuroendocrine tumor patients treated with [177Lu]Lu-DOTA-TATE.
Santoro-Fernandes V, Schott B, Deatsch A, Keigley Q, Francken T, Iyer R, Fountzilas C, Perlman S, Jeraj R. Santoro-Fernandes V, et al. Among authors: iyer r. Eur J Nucl Med Mol Imaging. 2024 May 25. doi: 10.1007/s00259-024-06767-x. Online ahead of print. Eur J Nucl Med Mol Imaging. 2024. PMID: 38795121
Reducing postoperative hypothermia in infants: Quality improvement in China.
Qiu Q, Yang Z, Zhang Y, Zeng W, Yang K, Liang C, Alifu A, Huang H, Chen J, Zhang M, Wu D, Guo X, Jin S, Lin Y, Chuo J, Zhang H, Song X, Iyer RS. Qiu Q, et al. Among authors: iyer rs. Paediatr Anaesth. 2024 May 22. doi: 10.1111/pan.14910. Online ahead of print. Paediatr Anaesth. 2024. PMID: 38775778
1,554 results