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Keratinocyte growth factor impairs human thymic recovery from lymphopenia.
JCI Insight. 2019 May 7;5(12):e125377. doi: 10.1172/jci.insight.125377.
JCI Insight. 2019.
PMID: 31063156
Free PMC article.
Clinical Trial.
The MS Remyelinating Drug Bexarotene (an RXR Agonist) Promotes Induction of Human Tregs and Suppresses Th17 Differentiation In Vitro.
Gaunt CM, Rainbow DB, Mackenzie RJ, Jarvis LB, Mousa HS, Cunniffe N, Georgieva Z, Brown JW, Coles AJ, Jones JL.
Gaunt CM, et al.
Front Immunol. 2021 Aug 10;12:712241. doi: 10.3389/fimmu.2021.712241. eCollection 2021.
Front Immunol. 2021.
PMID: 34447379
Free PMC article.
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Diminished seroconversion following a single SARS-COV-2 vaccine in ocrelizumab-treated relapsing-remitting multiple sclerosis patients.
Georgieva ZG, Dӧffinger R, Kumararatne D, Coles AJ, McCarthy C.
Georgieva ZG, et al.
Mult Scler. 2022 Jun;28(7):1126-1130. doi: 10.1177/13524585211046786. Epub 2021 Oct 1.
Mult Scler. 2022.
PMID: 34595965
Free PMC article.
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Safety and efficacy of bexarotene in patients with relapsing-remitting multiple sclerosis (CCMR One): a randomised, double-blind, placebo-controlled, parallel-group, phase 2a study.
Brown JWL, Cunniffe NG, Prados F, Kanber B, Jones JL, Needham E, Georgieva Z, Rog D, Pearson OR, Overell J, MacManus D, Samson RS, Stutters J, Ffrench-Constant C, Gandini Wheeler-Kingshott CAM, Moran C, Flynn PD, Michell AW, Franklin RJM, Chandran S, Altmann DR, Chard DT, Connick P, Coles AJ.
Brown JWL, et al.
Lancet Neurol. 2021 Sep;20(9):709-720. doi: 10.1016/S1474-4422(21)00179-4.
Lancet Neurol. 2021.
PMID: 34418398
Clinical Trial.
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Remyelination varies between and within lesions in multiple sclerosis following bexarotene.
Brown JWL, Prados F, Altmann DR, Kanber B, Stutters J, Cunniffe NG, Jones JL, Georgieva ZG, Needham EJ, Daruwalla C, Wheeler-Kingshott CG, Connick P, Chandran S, Franklin R, MacManus D, Samson R, Coles A, Chard D.
Brown JWL, et al. Among authors: georgieva zg.
Ann Clin Transl Neurol. 2022 Oct;9(10):1626-1642. doi: 10.1002/acn3.51662. Epub 2022 Sep 17.
Ann Clin Transl Neurol. 2022.
PMID: 36116011
Free PMC article.
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Extracellular Lactate: A Novel Measure of T Cell Proliferation.
Grist JT, Jarvis LB, Georgieva Z, Thompson S, Kaur Sandhu H, Burling K, Clarke A, Jackson S, Wills M, Gallagher FA, Jones JL.
Grist JT, et al.
J Immunol. 2018 Feb 1;200(3):1220-1226. doi: 10.4049/jimmunol.1700886. Epub 2017 Dec 29.
J Immunol. 2018.
PMID: 29288205
Free PMC article.
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Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73.
Jarvis LB, Rainbow DB, Coppard V, Howlett SK, Georgieva Z, Davies JL, Mullay HK, Hester J, Ashmore T, Van Den Bosch A, Grist JT, Coles AJ, Mousa HS, Pluchino S, Mahbubani KT, Griffin JL, Saeb-Parsy K, Issa F, Peruzzotti-Jametti L, Wicker LS, Jones JL.
Jarvis LB, et al.
Commun Biol. 2021 Oct 14;4(1):1186. doi: 10.1038/s42003-021-02721-x.
Commun Biol. 2021.
PMID: 34650224
Free PMC article.
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Cerebellar ataxia and epilepsy with anti-GAD antibodies: treatment with IVIG and plasmapheresis.
Georgieva Z, Parton M.
Georgieva Z, et al.
BMJ Case Rep. 2014 Jan 13;2014:bcr2013202314. doi: 10.1136/bcr-2013-202314.
BMJ Case Rep. 2014.
PMID: 24419643
Free PMC article.
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