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De novo design of tunable, pH-driven conformational changes.
Boyken SE, Benhaim MA, Busch F, Jia M, Bick MJ, Choi H, Klima JC, Chen Z, Walkey C, Mileant A, Sahasrabuddhe A, Wei KY, Hodge EA, Byron S, Quijano-Rubio A, Sankaran B, King NP, Lippincott-Schwartz J, Wysocki VH, Lee KK, Baker D. Boyken SE, et al. Science. 2019 May 17;364(6441):658-664. doi: 10.1126/science.aav7897. Science. 2019. PMID: 31097662 Free PMC article.
Correlative three-dimensional super-resolution and block-face electron microscopy of whole vitreously frozen cells.
Hoffman DP, Shtengel G, Xu CS, Campbell KR, Freeman M, Wang L, Milkie DE, Pasolli HA, Iyer N, Bogovic JA, Stabley DR, Shirinifard A, Pang S, Peale D, Schaefer K, Pomp W, Chang CL, Lippincott-Schwartz J, Kirchhausen T, Solecki DJ, Betzig E, Hess HF. Hoffman DP, et al. Science. 2020 Jan 17;367(6475):eaaz5357. doi: 10.1126/science.aaz5357. Science. 2020. PMID: 31949053 Free PMC article.
Imaging intracellular fluorescent proteins at nanometer resolution.
Betzig E, Patterson GH, Sougrat R, Lindwasser OW, Olenych S, Bonifacino JS, Davidson MW, Lippincott-Schwartz J, Hess HF. Betzig E, et al. Science. 2006 Sep 15;313(5793):1642-5. doi: 10.1126/science.1127344. Epub 2006 Aug 10. Science. 2006. PMID: 16902090
Lattice light-sheet microscopy: imaging molecules to embryos at high spatiotemporal resolution.
Chen BC, Legant WR, Wang K, Shao L, Milkie DE, Davidson MW, Janetopoulos C, Wu XS, Hammer JA 3rd, Liu Z, English BP, Mimori-Kiyosue Y, Romero DP, Ritter AT, Lippincott-Schwartz J, Fritz-Laylin L, Mullins RD, Mitchell DM, Bembenek JN, Reymann AC, Böhme R, Grill SW, Wang JT, Seydoux G, Tulu US, Kiehart DP, Betzig E. Chen BC, et al. Science. 2014 Oct 24;346(6208):1257998. doi: 10.1126/science.1257998. Epub 2014 Oct 23. Science. 2014. PMID: 25342811 Free PMC article.
Bright photoactivatable fluorophores for single-molecule imaging.
Grimm JB, English BP, Choi H, Muthusamy AK, Mehl BP, Dong P, Brown TA, Lippincott-Schwartz J, Liu Z, Lionnet T, Lavis LD. Grimm JB, et al. Nat Methods. 2016 Dec;13(12):985-988. doi: 10.1038/nmeth.4034. Epub 2016 Oct 24. Nat Methods. 2016. PMID: 27776112
mTOR-dependent phosphorylation controls TFEB nuclear export.
Napolitano G, Esposito A, Choi H, Matarese M, Benedetti V, Di Malta C, Monfregola J, Medina DL, Lippincott-Schwartz J, Ballabio A. Napolitano G, et al. Nat Commun. 2018 Aug 17;9(1):3312. doi: 10.1038/s41467-018-05862-6. Nat Commun. 2018. PMID: 30120233 Free PMC article.
Cortical column and whole-brain imaging with molecular contrast and nanoscale resolution.
Gao R, Asano SM, Upadhyayula S, Pisarev I, Milkie DE, Liu TL, Singh V, Graves A, Huynh GH, Zhao Y, Bogovic J, Colonell J, Ott CM, Zugates C, Tappan S, Rodriguez A, Mosaliganti KR, Sheu SH, Pasolli HA, Pang S, Xu CS, Megason SG, Hess H, Lippincott-Schwartz J, Hantman A, Rubin GM, Kirchhausen T, Saalfeld S, Aso Y, Boyden ES, Betzig E. Gao R, et al. Science. 2019 Jan 18;363(6424):eaau8302. doi: 10.1126/science.aau8302. Science. 2019. PMID: 30655415 Free PMC article.
A general method to optimize and functionalize red-shifted rhodamine dyes.
Grimm JB, Tkachuk AN, Xie L, Choi H, Mohar B, Falco N, Schaefer K, Patel R, Zheng Q, Liu Z, Lippincott-Schwartz J, Brown TA, Lavis LD. Grimm JB, et al. Nat Methods. 2020 Aug;17(8):815-821. doi: 10.1038/s41592-020-0909-6. Epub 2020 Jul 27. Nat Methods. 2020. PMID: 32719532 Free PMC article.
A General Method to Improve Fluorophores Using Deuterated Auxochromes.
Grimm JB, Xie L, Casler JC, Patel R, Tkachuk AN, Falco N, Choi H, Lippincott-Schwartz J, Brown TA, Glick BS, Liu Z, Lavis LD. Grimm JB, et al. JACS Au. 2021 May 24;1(5):690-696. doi: 10.1021/jacsau.1c00006. Epub 2021 Apr 23. JACS Au. 2021. PMID: 34056637 Free PMC article.
322 results