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Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism.
EMBO Mol Med. 2019 Jun;11(6):e9711. doi: 10.15252/emmm.201809711.
EMBO Mol Med. 2019.
PMID: 31122931
Free PMC article.
Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice.
Götzl JK, Colombo AV, Fellerer K, Reifschneider A, Werner G, Tahirovic S, Haass C, Capell A.
Götzl JK, et al.
Mol Neurodegener. 2018 Sep 4;13(1):48. doi: 10.1186/s13024-018-0281-5.
Mol Neurodegener. 2018.
PMID: 30180904
Free PMC article.
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Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency.
Reifschneider A, Robinson S, van Lengerich B, Gnörich J, Logan T, Heindl S, Vogt MA, Weidinger E, Riedl L, Wind K, Zatcepin A, Pesämaa I, Haberl S, Nuscher B, Kleinberger G, Klimmt J, Götzl JK, Liesz A, Bürger K, Brendel M, Levin J, Diehl-Schmid J, Suh J, Di Paolo G, Lewcock JW, Monroe KM, Paquet D, Capell A, Haass C.
Reifschneider A, et al. Among authors: gotzl jk.
EMBO J. 2022 Feb 15;41(4):e109108. doi: 10.15252/embj.2021109108. Epub 2022 Jan 12.
EMBO J. 2022.
PMID: 35019161
Free PMC article.
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Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis.
Götzl JK, Mori K, Damme M, Fellerer K, Tahirovic S, Kleinberger G, Janssens J, van der Zee J, Lang CM, Kremmer E, Martin JJ, Engelborghs S, Kretzschmar HA, Arzberger T, Van Broeckhoven C, Haass C, Capell A.
Götzl JK, et al.
Acta Neuropathol. 2014;127(6):845-60. doi: 10.1007/s00401-014-1262-6. Epub 2014 Mar 12.
Acta Neuropathol. 2014.
PMID: 24619111
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Impaired protein degradation in FTLD and related disorders.
Götzl JK, Lang CM, Haass C, Capell A.
Götzl JK, et al.
Ageing Res Rev. 2016 Dec;32:122-139. doi: 10.1016/j.arr.2016.04.008. Epub 2016 May 7.
Ageing Res Rev. 2016.
PMID: 27166223
Review.
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