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A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.
van der Lee SJ, Conway OJ, Jansen I, Carrasquillo MM, Kleineidam L, van den Akker E, Hernández I, van Eijk KR, Stringa N, Chen JA, Zettergren A, Andlauer TFM, Diez-Fairen M, Simon-Sanchez J, Lleó A, Zetterberg H, Nygaard M, Blauwendraat C, Savage JE, Mengel-From J, Moreno-Grau S, Wagner M, Fortea J, Keogh MJ, Blennow K, Skoog I, Friese MA, Pletnikova O, Zulaica M, Lage C, de Rojas I, Riedel-Heller S, Illán-Gala I, Wei W, Jeune B, Orellana A, Then Bergh F, Wang X, Hulsman M, Beker N, Tesi N, Morris CM, Indakoetxea B, Collij LE, Scherer M, Morenas-Rodríguez E, Ironside JW, van Berckel BNM, Alcolea D, Wiendl H, Strickland SL, Pastor P, Rodríguez Rodríguez E; DESGESCO (Dementia Genetics Spanish Consortium), EADB (Alzheimer Disease European DNA biobank); EADB (Alzheimer Disease European DNA biobank); IFGC (International FTD-Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium); IPDGC (The International Parkinson Disease Genomics Consortium); RiMod-FTD (Risk and Modifying factors in Fronto-Temporal Dementia); Netherlands Brain Bank (NBB); Boeve BF, Petersen RC, Ferman TJ, van Gerpen JA, Reinders MJT, Uitti RJ, Tárraga L, Maier W, Dols-Icardo O, Kaw… See abstract for full author list ➔ van der Lee SJ, et al. Among authors: kleineidam l. Acta Neuropathol. 2019 Aug;138(2):237-250. doi: 10.1007/s00401-019-02026-8. Epub 2019 May 27. Acta Neuropathol. 2019. PMID: 31131421 Free PMC article.
[Longitudinal Predictors of the Need for Care].
Hajek A, Brettschneider C, Ernst A, Posselt T, Mamone S, Wiese B, Weyerer S, Werle J, Pentzek M, Fuchs A, Stein J, Luck T, Bickel H, Mösch E, Kleineidam L, Heser K, Maier W, Scherer M, Riedel-Heller SG, König HH. Hajek A, et al. Among authors: kleineidam l. Gesundheitswesen. 2017 Feb;79(2):73-79. doi: 10.1055/s-0041-111841. Epub 2016 Apr 7. Gesundheitswesen. 2017. PMID: 27056709 German.
Differential Risk of Incident Alzheimer's Disease Dementia in Stable Versus Unstable Patterns of Subjective Cognitive Decline.
Wolfsgruber S, Kleineidam L, Wagner M, Mösch E, Bickel H, Lϋhmann D, Ernst A, Wiese B, Steinmann S, König HH, Brettschneider C, Luck T, Stein J, Weyerer S, Werle J, Pentzek M, Fuchs A, Maier W, Scherer M, Riedel-Heller SG, Jessen F; AgeCoDe Study Group. Wolfsgruber S, et al. Among authors: kleineidam l. J Alzheimers Dis. 2016 Oct 4;54(3):1135-1146. doi: 10.3233/JAD-160407. J Alzheimers Dis. 2016. PMID: 27567852
Impact of coronary heart disease on cognitive decline in Alzheimer's disease: a prospective longitudinal cohort study in primary care.
Bleckwenn M, Kleineidam L, Wagner M, Jessen F, Weyerer S, Werle J, Wiese B, Lühmann D, Posselt T, König HH, Brettschneider C, Mösch E, Weeg D, Fuchs A, Pentzek M, Luck T, Riedel-Heller SG, Maier W, Scherer M. Bleckwenn M, et al. Among authors: kleineidam l. Br J Gen Pract. 2017 Feb;67(655):e111-e117. doi: 10.3399/bjgp16X688813. Epub 2016 Dec 19. Br J Gen Pract. 2017. PMID: 27993897 Free PMC article.
Cognitive functioning in the general population: Factor structure and association with mental disorders-The neuropsychological test battery of the mental health module of the German Health Interview and Examination Survey for Adults (DEGS1-MH).
Wagner M, Wolfsgruber S, Gaertner B, Kleineidam L, Buttery AK, Jacobi F, Van der Elst W, Jolles J, Hapke U, Wittchen HU, Maier W, Busch MA. Wagner M, et al. Among authors: kleineidam l. Int J Methods Psychiatr Res. 2018 Mar;27(1):e1594. doi: 10.1002/mpr.1594. Epub 2017 Nov 6. Int J Methods Psychiatr Res. 2018. PMID: 29105877 Free PMC article.
Prospective Associations between Single Foods, Alzheimer's Dementia and Memory Decline in the Elderly.
Fischer K, Melo van Lent D, Wolfsgruber S, Weinhold L, Kleineidam L, Bickel H, Scherer M, Eisele M, van den Bussche H, Wiese B, König HH, Weyerer S, Pentzek M, Röhr S, Maier W, Jessen F, Schmid M, Riedel-Heller SG, Wagner M. Fischer K, et al. Among authors: kleineidam l. Nutrients. 2018 Jun 29;10(7):852. doi: 10.3390/nu10070852. Nutrients. 2018. PMID: 29966314 Free PMC article.
What Is Successful Aging? A Psychometric Validation Study of Different Construct Definitions.
Kleineidam L, Thoma MV, Maercker A, Bickel H, Mösch E, Hajek A, König HH, Eisele M, Mallon T, Luck T, Röhr S, Weyerer S, Werle J, Pentzek M, Fuchs A, Wiese B, Mamone S, Scherer M, Maier W, Riedel-Heller SG, Wagner M. Kleineidam L, et al. Gerontologist. 2019 Jul 16;59(4):738-748. doi: 10.1093/geront/gny083. Gerontologist. 2019. PMID: 30016435
Exploring Genetic Associations of Alzheimer's Disease Loci With Mild Cognitive Impairment Neurocognitive Endophenotypes.
Espinosa A, Hernández-Olasagarre B, Moreno-Grau S, Kleineidam L, Heilmann-Heimbach S, Hernández I, Wolfsgruber S, Wagner H, Rosende-Roca M, Mauleón A, Vargas L, Lafuente A, Rodríguez-Gómez O, Abdelnour C, Gil S, Marquié M, Santos-Santos MA, Sanabria Á, Ortega G, Monté-Rubio G, Pérez A, Ibarria M, Ruiz S, Kornhuber J, Peters O, Frölich L, Hüll M, Wiltfang J, Luck T, Riedel-Heller S, Montrreal L, Cañabate P, Moreno M, Preckler S, Aguilera N, de Rojas I, Orellana A, Alegret M, Valero S, Nöthen MM, Wagner M, Jessen F, Tárraga L, Boada M, Ramírez A, Ruiz A. Espinosa A, et al. Among authors: kleineidam l. Front Aging Neurosci. 2018 Oct 30;10:340. doi: 10.3389/fnagi.2018.00340. eCollection 2018. Front Aging Neurosci. 2018. PMID: 30425636 Free PMC article.
Computer-assisted prediction of clinical progression in the earliest stages of AD.
Rhodius-Meester HFM, Liedes H, Koikkalainen J, Wolfsgruber S, Coll-Padros N, Kornhuber J, Peters O, Jessen F, Kleineidam L, Molinuevo JL, Rami L, Teunissen CE, Barkhof F, Sikkes SAM, Wesselman LMP, Slot RER, Verfaillie SCJ, Scheltens P, Tijms BM, Lötjönen J, van der Flier WM. Rhodius-Meester HFM, et al. Among authors: kleineidam l. Alzheimers Dement (Amst). 2018 Oct 8;10:726-736. doi: 10.1016/j.dadm.2018.09.001. eCollection 2018. Alzheimers Dement (Amst). 2018. PMID: 30619929 Free PMC article.
81 results