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A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.
van der Lee SJ, Conway OJ, Jansen I, Carrasquillo MM, Kleineidam L, van den Akker E, Hernández I, van Eijk KR, Stringa N, Chen JA, Zettergren A, Andlauer TFM, Diez-Fairen M, Simon-Sanchez J, Lleó A, Zetterberg H, Nygaard M, Blauwendraat C, Savage JE, Mengel-From J, Moreno-Grau S, Wagner M, Fortea J, Keogh MJ, Blennow K, Skoog I, Friese MA, Pletnikova O, Zulaica M, Lage C, de Rojas I, Riedel-Heller S, Illán-Gala I, Wei W, Jeune B, Orellana A, Then Bergh F, Wang X, Hulsman M, Beker N, Tesi N, Morris CM, Indakoetxea B, Collij LE, Scherer M, Morenas-Rodríguez E, Ironside JW, van Berckel BNM, Alcolea D, Wiendl H, Strickland SL, Pastor P, Rodríguez Rodríguez E; DESGESCO (Dementia Genetics Spanish Consortium), EADB (Alzheimer Disease European DNA biobank); EADB (Alzheimer Disease European DNA biobank); IFGC (International FTD-Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium); IPDGC (The International Parkinson Disease Genomics Consortium); RiMod-FTD (Risk and Modifying factors in Fronto-Temporal Dementia); Netherlands Brain Bank (NBB); Boeve BF, Petersen RC, Ferman TJ, van Gerpen JA, Reinders MJT, Uitti RJ, Tárraga L, Maier W, Dols-Icardo O, Kaw… See abstract for full author list ➔ van der Lee SJ, et al. Among authors: scherer m. Acta Neuropathol. 2019 Aug;138(2):237-250. doi: 10.1007/s00401-019-02026-8. Epub 2019 May 27. Acta Neuropathol. 2019. PMID: 31131421 Free PMC article.
AD dementia risk in late MCI, in early MCI, and in subjective memory impairment.
Jessen F, Wolfsgruber S, Wiese B, Bickel H, Mösch E, Kaduszkiewicz H, Pentzek M, Riedel-Heller SG, Luck T, Fuchs A, Weyerer S, Werle J, van den Bussche H, Scherer M, Maier W, Wagner M; German Study on Aging, Cognition and Dementia in Primary Care Patients. Jessen F, et al. Among authors: scherer m. Alzheimers Dement. 2014 Jan;10(1):76-83. doi: 10.1016/j.jalz.2012.09.017. Epub 2013 Jan 30. Alzheimers Dement. 2014. PMID: 23375567
Depression, non-fatal stroke and all-cause mortality in old age: a prospective cohort study of primary care patients.
Köhler S, Verhey F, Weyerer S, Wiese B, Heser K, Wagner M, Pentzek M, Fuchs A, Köhler M, Bachmann C, Riedel Heller SG, Luppa M, Eifflaender-Gorfer S, Werle J, Bickel H, Mösch E, König HH, Brettschneider C, Scherer M, Maier W. Köhler S, et al. Among authors: scherer m. J Affect Disord. 2013 Aug 15;150(1):63-9. doi: 10.1016/j.jad.2013.02.020. Epub 2013 Mar 7. J Affect Disord. 2013. PMID: 23474092 Free article.
The CERAD neuropsychological assessment battery total score detects and predicts Alzheimer disease dementia with high diagnostic accuracy.
Wolfsgruber S, Jessen F, Wiese B, Stein J, Bickel H, Mösch E, Weyerer S, Werle J, Pentzek M, Fuchs A, Köhler M, Bachmann C, Riedel-Heller SG, Scherer M, Maier W, Wagner M; AgeCoDe Study Group. Wolfsgruber S, et al. Among authors: scherer m. Am J Geriatr Psychiatry. 2014 Oct;22(10):1017-28. doi: 10.1016/j.jagp.2012.08.021. Epub 2013 Jun 4. Am J Geriatr Psychiatry. 2014. PMID: 23759289
The costs of dementia from the societal perspective: is care provided in the community really cheaper than nursing home care?
König HH, Leicht H, Brettschneider C, Bachmann C, Bickel H, Fuchs A, Jessen F, Köhler M, Luppa M, Mösch E, Pentzek M, Werle J, Weyerer S, Wiese B, Scherer M, Maier W, Riedel-Heller SG; AgeCoDe Study Group. König HH, et al. Among authors: scherer m. J Am Med Dir Assoc. 2014 Feb;15(2):117-26. doi: 10.1016/j.jamda.2013.10.003. Epub 2013 Dec 8. J Am Med Dir Assoc. 2014. PMID: 24321877
Impact of depression on health care utilization and costs among multimorbid patients--from the MultiCare Cohort Study.
Bock JO, Luppa M, Brettschneider C, Riedel-Heller S, Bickel H, Fuchs A, Gensichen J, Maier W, Mergenthal K, Schäfer I, Schön G, Weyerer S, Wiese B, van den Bussche H, Scherer M, König HH. Bock JO, et al. Among authors: scherer m. PLoS One. 2014 Mar 17;9(3):e91973. doi: 10.1371/journal.pone.0091973. eCollection 2014. PLoS One. 2014. PMID: 24638040 Free PMC article.
Risk of dementia in elderly patients with the use of proton pump inhibitors.
Haenisch B, von Holt K, Wiese B, Prokein J, Lange C, Ernst A, Brettschneider C, König HH, Werle J, Weyerer S, Luppa M, Riedel-Heller SG, Fuchs A, Pentzek M, Weeg D, Bickel H, Broich K, Jessen F, Maier W, Scherer M. Haenisch B, et al. Among authors: scherer m. Eur Arch Psychiatry Clin Neurosci. 2015 Aug;265(5):419-28. doi: 10.1007/s00406-014-0554-0. Epub 2014 Oct 24. Eur Arch Psychiatry Clin Neurosci. 2015. PMID: 25341874
Elevated HbA1c is associated with increased risk of incident dementia in primary care patients.
Ramirez A, Wolfsgruber S, Lange C, Kaduszkiewicz H, Weyerer S, Werle J, Pentzek M, Fuchs A, Riedel-Heller SG, Luck T, Mösch E, Bickel H, Wiese B, Prokein J, König HH, Brettschneider C, Breteler MM, Maier W, Jessen F, Scherer M; AgeCoDe Study Group. Ramirez A, et al. Among authors: scherer m. J Alzheimers Dis. 2015;44(4):1203-12. doi: 10.3233/JAD-141521. J Alzheimers Dis. 2015. PMID: 25524954
Associations between Dementia Outcomes and Depressive Symptoms, Leisure Activities, and Social Support.
Heser K, Wagner M, Wiese B, Prokein J, Ernst A, König HH, Brettschneider C, Riedel-Heller SG, Luppa M, Weyerer S, Eifflaender-Gorfer S, Bickel H, Mösch E, Pentzek M, Fuchs A, Maier W, Scherer M, Eisele M; AgeCoDe Study Group. Heser K, et al. Among authors: scherer m. Dement Geriatr Cogn Dis Extra. 2014 Dec 10;4(3):481-93. doi: 10.1159/000368189. eCollection 2014 Sep-Dec. Dement Geriatr Cogn Dis Extra. 2014. PMID: 25685139 Free PMC article.
PLD3 in non-familial Alzheimer's disease.
Heilmann S, Drichel D, Clarimon J, Fernández V, Lacour A, Wagner H, Thelen M, Hernández I, Fortea J, Alegret M, Blesa R, Mauleón A, Roca MR, Kornhuber J, Peters O, Heun R, Frölich L, Hüll M, Heneka MT, Rüther E, Riedel-Heller S, Scherer M, Wiltfang J, Jessen F, Becker T, Tárraga L, Boada M, Maier W, Lleó A, Ruiz A, Nöthen MM, Ramirez A. Heilmann S, et al. Among authors: scherer m. Nature. 2015 Apr 2;520(7545):E3-5. doi: 10.1038/nature14039. Nature. 2015. PMID: 25832411 No abstract available.
1,270 results