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Curcumin Combined with FOLFOX Chemotherapy Is Safe and Tolerable in Patients with Metastatic Colorectal Cancer in a Randomized Phase IIa Trial.
Howells LM, Iwuji COO, Irving GRB, Barber S, Walter H, Sidat Z, Griffin-Teall N, Singh R, Foreman N, Patel SR, Morgan B, Steward WP, Gescher A, Thomas AL, Brown K. Howells LM, et al. Among authors: thomas al. J Nutr. 2019 Jul 1;149(7):1133-1139. doi: 10.1093/jn/nxz029. J Nutr. 2019. PMID: 31132111 Free PMC article. Clinical Trial.
Curcumin inhibits cancer stem cell phenotypes in ex vivo models of colorectal liver metastases, and is clinically safe and tolerable in combination with FOLFOX chemotherapy.
James MI, Iwuji C, Irving G, Karmokar A, Higgins JA, Griffin-Teal N, Thomas A, Greaves P, Cai H, Patel SR, Morgan B, Dennison A, Metcalfe M, Garcea G, Lloyd DM, Berry DP, Steward WP, Howells LM, Brown K. James MI, et al. Cancer Lett. 2015 Aug 10;364(2):135-41. doi: 10.1016/j.canlet.2015.05.005. Epub 2015 May 12. Cancer Lett. 2015. PMID: 25979230 Free PMC article. Clinical Trial.
Increased mitochondrial proline metabolism sustains proliferation and survival of colorectal cancer cells.
Alaqbi SS, Burke L, Guterman I, Green C, West K, Palacios-Gallego R, Cai H, Alexandrou C, Myint NNM, Parrott E, Howells LM, Higgins JA, Jones DJL, Singh R, Britton RG, Tufarelli C, Thomas A, Rufini A. Alaqbi SS, et al. PLoS One. 2022 Feb 7;17(2):e0262364. doi: 10.1371/journal.pone.0262364. eCollection 2022. PLoS One. 2022. PMID: 35130302 Free PMC article.
304 results