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Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter.
Nat Commun. 2019 Jun 3;10(1):2399. doi: 10.1038/s41467-019-10352-4.
Nat Commun. 2019.
PMID: 31160585
Free PMC article.
An engineered chimeric toxin that cleaves activated mutant and wild-type RAS inhibits tumor growth.
Vidimar V, Beilhartz GL, Park M, Biancucci M, Kieffer MB, Gius DR, Melnyk RA, Satchell KJF.
Vidimar V, et al. Among authors: kieffer mb.
Proc Natl Acad Sci U S A. 2020 Jul 21;117(29):16938-16948. doi: 10.1073/pnas.2000312117. Epub 2020 Jul 2.
Proc Natl Acad Sci U S A. 2020.
PMID: 32616570
Free PMC article.
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The bacterial Ras/Rap1 site-specific endopeptidase RRSP cleaves Ras through an atypical mechanism to disrupt Ras-ERK signaling.
Biancucci M, Minasov G, Banerjee A, Herrera A, Woida PJ, Kieffer MB, Bindu L, Abreu-Blanco M, Anderson WF, Gaponenko V, Stephen AG, Holderfield M, Satchell KJF.
Biancucci M, et al. Among authors: kieffer mb.
Sci Signal. 2018 Oct 2;11(550):eaat8335. doi: 10.1126/scisignal.aat8335.
Sci Signal. 2018.
PMID: 30279169
Free PMC article.
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Antibodies against a secreted product of Staphylococcus aureus trigger phagocytic killing.
Thomer L, Emolo C, Thammavongsa V, Kim HK, McAdow ME, Yu W, Kieffer M, Schneewind O, Missiakas D.
Thomer L, et al.
J Exp Med. 2016 Mar 7;213(3):293-301. doi: 10.1084/jem.20150074. Epub 2016 Feb 15.
J Exp Med. 2016.
PMID: 26880578
Free PMC article.
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