Mazzetti AP - Search Results

1

A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1.

De Luca A, Parker LJ, Ang WH, Rodolfo C, Gabbarini V, Hancock NC, Palone F, Mazzetti AP, Menin L, Morton CJ, Parker MW, Lo Bello M, Dyson PJ. De Luca A, et al. Among authors: mazzetti ap. Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):13943-13951. doi: 10.1073/pnas.1903297116. Epub 2019 Jun 20. Proc Natl Acad Sci U S A. 2019. PMID: 31221747 Free PMC article.

2

Influence of the H-site residue 108 on human glutathione transferase P1-1 ligand binding: structure-thermodynamic relationships and thermal stability.

Quesada-Soriano I, Parker LJ, Primavera A, Casas-Solvas JM, Vargas-Berenguel A, Barón C, Morton CJ, Mazzetti AP, Lo Bello M, Parker MW, García-Fuentes L. Quesada-Soriano I, et al. Among authors: mazzetti ap. Protein Sci. 2009 Dec;18(12):2454-70. doi: 10.1002/pro.253. Protein Sci. 2009. PMID: 19780048 Free PMC article.

3

Engineering a new C-terminal tail in the H-site of human glutathione transferase P1-1: structural and functional consequences.

Micaloni C, Kong GK, Mazzetti AP, Nuccetelli M, Antonini G, Stella L, McKinstry WJ, Polekhina G, Rossjohn J, Federici G, Ricci G, Parker MW, Lo Bello M. Micaloni C, et al. Among authors: mazzetti ap. J Mol Biol. 2003 Jan 3;325(1):111-22. doi: 10.1016/s0022-2836(02)01178-6. J Mol Biol. 2003. PMID: 12473455

4

Nitrosylation of human glutathione transferase P1-1 with dinitrosyl diglutathionyl iron complex in vitro and in vivo.

Cesareo E, Parker LJ, Pedersen JZ, Nuccetelli M, Mazzetti AP, Pastore A, Federici G, Caccuri AM, Ricci G, Adams JJ, Parker MW, Lo Bello M. Cesareo E, et al. Among authors: mazzetti ap. J Biol Chem. 2005 Dec 23;280(51):42172-80. doi: 10.1074/jbc.M507916200. Epub 2005 Sep 29. J Biol Chem. 2005. PMID: 16195232 Free article.

5

Multifunctional role of Tyr 108 in the catalytic mechanism of human glutathione transferase P1-1. Crystallographic and kinetic studies on the Y108F mutant enzyme.

Lo Bello M, Oakley AJ, Battistoni A, Mazzetti AP, Nuccetelli M, Mazzarese G, Rossjohn J, Parker MW, Ricci G. Lo Bello M, et al. Among authors: mazzetti ap. Biochemistry. 1997 May 20;36(20):6207-17. doi: 10.1021/bi962813z. Biochemistry. 1997. PMID: 9166793

6

The glutathione conjugate of ethacrynic acid can bind to human pi class glutathione transferase P1-1 in two different modes.

Oakley AJ, Lo Bello M, Mazzetti AP, Federici G, Parker MW. Oakley AJ, et al. Among authors: mazzetti ap. FEBS Lett. 1997 Dec 8;419(1):32-6. doi: 10.1016/s0014-5793(97)01424-5. FEBS Lett. 1997. PMID: 9426214 Free article.

7

Mutations of Gly to Ala in human glutathione transferase P1-1 affect helix 2 (G-site) and induce positive cooperativity in the binding of glutathione.

Lo Bello M, Nuccetelli M, Chiessi E, Lahm A, Mazzetti AP, Battistoni A, Caccuri AM, Oakley AJ, Parker MW, Tramontano A, Federici G, Ricci G. Lo Bello M, et al. Among authors: mazzetti ap. J Mol Biol. 1998 Dec 18;284(5):1717-25. doi: 10.1006/jmbi.1998.2270. J Mol Biol. 1998. PMID: 9878382

8

The ligandin (non-substrate) binding site of human Pi class glutathione transferase is located in the electrophile binding site (H-site).

Oakley AJ, Lo Bello M, Nuccetelli M, Mazzetti AP, Parker MW. Oakley AJ, et al. Among authors: mazzetti ap. J Mol Biol. 1999 Aug 27;291(4):913-26. doi: 10.1006/jmbi.1999.3029. J Mol Biol. 1999. PMID: 10452896

9

Glutathione transferases and neurodegenerative diseases.

Mazzetti AP, Fiorile MC, Primavera A, Lo Bello M. Mazzetti AP, et al. Neurochem Int. 2015 Mar;82:10-8. doi: 10.1016/j.neuint.2015.01.008. Epub 2015 Feb 7. Neurochem Int. 2015. PMID: 25661512 Review.

10

Diuretic drug binding to human glutathione transferase P1-1: potential role of Cys-101 revealed in the double mutant C47S/Y108V.

Quesada-Soriano I, Parker LJ, Primavera A, Wielens J, Holien JK, Casas-Solvas JM, Vargas-Berenguel A, Aguilera AM, Nuccetelli M, Mazzetti AP, Lo Bello M, Parker MW, García-Fuentes L. Quesada-Soriano I, et al. Among authors: mazzetti ap. J Mol Recognit. 2011 Mar-Apr;24(2):220-34. doi: 10.1002/jmr.1040. J Mol Recognit. 2011. PMID: 20540076

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