Parker MW - Search Results

1

A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1.

De Luca A, Parker LJ, Ang WH, Rodolfo C, Gabbarini V, Hancock NC, Palone F, Mazzetti AP, Menin L, Morton CJ, Parker MW, Lo Bello M, Dyson PJ. De Luca A, et al. Among authors: parker mw, parker lj. Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):13943-13951. doi: 10.1073/pnas.1903297116. Epub 2019 Jun 20. Proc Natl Acad Sci U S A. 2019. PMID: 31221747 Free PMC article.

2

Three-dimensional structure of class pi glutathione S-transferase from human placenta in complex with S-hexylglutathione at 2.8 A resolution.

Reinemer P, Dirr HW, Ladenstein R, Huber R, Lo Bello M, Federici G, Parker MW. Reinemer P, et al. Among authors: parker mw. J Mol Biol. 1992 Sep 5;227(1):214-26. doi: 10.1016/0022-2836(92)90692-d. J Mol Biol. 1992. PMID: 1522586

3

Crystallization of glutathione S-transferase from human placenta.

Parker MW, Lo Bello M, Federici G. Parker MW, et al. J Mol Biol. 1990 May 20;213(2):221-2. doi: 10.1016/s0022-2836(05)80183-4. J Mol Biol. 1990. PMID: 2342105

4

Site-directed mutagenesis of human glutathione transferase P1-1. Mutation of Cys-47 induces a positive cooperativity in glutathione transferase P1-1.

Ricci G, Lo Bello M, Caccurri AM, Pastore A, Nuccetelli M, Parker MW, Federici G. Ricci G, et al. Among authors: parker mw. J Biol Chem. 1995 Jan 20;270(3):1243-8. doi: 10.1074/jbc.270.3.1243. J Biol Chem. 1995. PMID: 7836386 Free article.

5

Conformational states of human placental glutathione transferase as probed by limited proteolysis.

Lo Bello M, Pastore A, Petruzzelli R, Parker MW, Wilce MC, Federici G, Ricci G. Lo Bello M, et al. Among authors: parker mw. Biochem Biophys Res Commun. 1993 Jul 30;194(2):804-10. doi: 10.1006/bbrc.1993.1893. Biochem Biophys Res Commun. 1993. PMID: 8343164

6

Peculiar spectroscopic and kinetic properties of Cys-47 in human placental glutathione transferase. Evidence for an atypical thiolate ion pair near the active site.

Lo Bello M, Parker MW, Desideri A, Polticelli F, Falconi M, Del Boccio G, Pennelli A, Federici G, Ricci G. Lo Bello M, et al. Among authors: parker mw. J Biol Chem. 1993 Sep 5;268(25):19033-8. J Biol Chem. 1993. PMID: 8360190 Free article.

7

The three-dimensional structure of the human Pi class glutathione transferase P1-1 in complex with the inhibitor ethacrynic acid and its glutathione conjugate.

Oakley AJ, Rossjohn J, Lo Bello M, Caccuri AM, Federici G, Parker MW. Oakley AJ, et al. Among authors: parker mw. Biochemistry. 1997 Jan 21;36(3):576-85. doi: 10.1021/bi962316i. Biochemistry. 1997. PMID: 9012673

8

Multifunctional role of Tyr 108 in the catalytic mechanism of human glutathione transferase P1-1. Crystallographic and kinetic studies on the Y108F mutant enzyme.

Lo Bello M, Oakley AJ, Battistoni A, Mazzetti AP, Nuccetelli M, Mazzarese G, Rossjohn J, Parker MW, Ricci G. Lo Bello M, et al. Among authors: parker mw. Biochemistry. 1997 May 20;36(20):6207-17. doi: 10.1021/bi962813z. Biochemistry. 1997. PMID: 9166793

9

Catalytic mechanism and role of hydroxyl residues in the active site of theta class glutathione S-transferases. Investigation of Ser-9 and Tyr-113 in a glutathione S-transferase from the Australian sheep blowfly, Lucilia cuprina.

Caccuri AM, Antonini G, Nicotra M, Battistoni A, Lo Bello M, Board PG, Parker MW, Ricci G. Caccuri AM, et al. Among authors: parker mw. J Biol Chem. 1997 Nov 21;272(47):29681-6. doi: 10.1074/jbc.272.47.29681. J Biol Chem. 1997. PMID: 9368035 Free article.

10

The structures of human glutathione transferase P1-1 in complex with glutathione and various inhibitors at high resolution.

Oakley AJ, Lo Bello M, Battistoni A, Ricci G, Rossjohn J, Villar HO, Parker MW. Oakley AJ, et al. Among authors: parker mw. J Mol Biol. 1997 Nov 21;274(1):84-100. doi: 10.1006/jmbi.1997.1364. J Mol Biol. 1997. PMID: 9398518

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