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Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure.
Cordero P, Parikh VN, Chin ET, Erbilgin A, Gloudemans MJ, Shang C, Huang Y, Chang AC, Smith KS, Dewey F, Zaleta K, Morley M, Brandimarto J, Glazer N, Waggott D, Pavlovic A, Zhao M, Moravec CS, Tang WHW, Skreen J, Malloy C, Hannenhalli S, Li H, Ritter S, Li M, Bernstein D, Connolly A, Hakonarson H, Lusis AJ, Margulies KB, Depaoli-Roach AA, Montgomery SB, Wheeler MT, Cappola T, Ashley EA. Cordero P, et al. Among authors: depaoli roach aa. Nat Commun. 2019 Jun 24;10(1):2760. doi: 10.1038/s41467-019-10591-5. Nat Commun. 2019. PMID: 31235787 Free PMC article.
PKC-alpha regulates cardiac contractility and propensity toward heart failure.
Braz JC, Gregory K, Pathak A, Zhao W, Sahin B, Klevitsky R, Kimball TF, Lorenz JN, Nairn AC, Liggett SB, Bodi I, Wang S, Schwartz A, Lakatta EG, DePaoli-Roach AA, Robbins J, Hewett TE, Bibb JA, Westfall MV, Kranias EG, Molkentin JD. Braz JC, et al. Nat Med. 2004 Mar;10(3):248-54. doi: 10.1038/nm1000. Epub 2004 Feb 15. Nat Med. 2004. PMID: 14966518 Free article.
Sterol regulatory element-binding protein-1 (SREBP-1) is required to regulate glycogen synthesis and gluconeogenic gene expression in mouse liver.
Ruiz R, Jideonwo V, Ahn M, Surendran S, Tagliabracci VS, Hou Y, Gamble A, Kerner J, Irimia-Dominguez JM, Puchowicz MA, DePaoli-Roach A, Hoppel C, Roach P, Morral N. Ruiz R, et al. J Biol Chem. 2014 Feb 28;289(9):5510-7. doi: 10.1074/jbc.M113.541110. Epub 2014 Jan 7. J Biol Chem. 2014. PMID: 24398675 Free PMC article.
Abnormal cardiac development in the absence of heart glycogen.
Pederson BA, Chen H, Schroeder JM, Shou W, DePaoli-Roach AA, Roach PJ. Pederson BA, et al. Mol Cell Biol. 2004 Aug;24(16):7179-87. doi: 10.1128/MCB.24.16.7179-7187.2004. Mol Cell Biol. 2004. PMID: 15282316 Free PMC article.
136 results