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Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure.
Cordero P, Parikh VN, Chin ET, Erbilgin A, Gloudemans MJ, Shang C, Huang Y, Chang AC, Smith KS, Dewey F, Zaleta K, Morley M, Brandimarto J, Glazer N, Waggott D, Pavlovic A, Zhao M, Moravec CS, Tang WHW, Skreen J, Malloy C, Hannenhalli S, Li H, Ritter S, Li M, Bernstein D, Connolly A, Hakonarson H, Lusis AJ, Margulies KB, Depaoli-Roach AA, Montgomery SB, Wheeler MT, Cappola T, Ashley EA. Cordero P, et al. Among authors: tang whw. Nat Commun. 2019 Jun 24;10(1):2760. doi: 10.1038/s41467-019-10591-5. Nat Commun. 2019. PMID: 31235787 Free PMC article.
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, Dugar B, Feldstein AE, Britt EB, Fu X, Chung YM, Wu Y, Schauer P, Smith JD, Allayee H, Tang WH, DiDonato JA, Lusis AJ, Hazen SL. Wang Z, et al. Nature. 2011 Apr 7;472(7341):57-63. doi: 10.1038/nature09922. Nature. 2011. PMID: 21475195 Free PMC article.
The chromosome 9p21.3 coronary heart disease risk allele is associated with altered gene expression in normal heart and vascular tissues.
Pilbrow AP, Folkersen L, Pearson JF, Brown CM, McNoe L, Wang NM, Sweet WE, Tang WH, Black MA, Troughton RW, Richards AM, Franco-Cereceda A, Gabrielsen A, Eriksson P, Moravec CS, Cameron VA. Pilbrow AP, et al. PLoS One. 2012;7(6):e39574. doi: 10.1371/journal.pone.0039574. Epub 2012 Jun 29. PLoS One. 2012. PMID: 22768093 Free PMC article.
Comparative genome-wide association studies in mice and humans for trimethylamine N-oxide, a proatherogenic metabolite of choline and L-carnitine.
Hartiala J, Bennett BJ, Tang WH, Wang Z, Stewart AF, Roberts R, McPherson R, Lusis AJ, Hazen SL, Allayee H; CARDIoGRAM Consortium. Hartiala J, et al. Arterioscler Thromb Vasc Biol. 2014 Jun;34(6):1307-13. doi: 10.1161/ATVBAHA.114.303252. Epub 2014 Mar 27. Arterioscler Thromb Vasc Biol. 2014. PMID: 24675659 Free PMC article.
831 results