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Divergent Cytotoxic and Metabolically Stimulative Functions of Sigma-2 Receptors: Structure-Activity Relationships of 6-Acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79) Derivatives.
Nicholson HE, Alsharif WF, Comeau AB, Mesangeau C, Intagliata S, Mottinelli M, McCurdy CR, Bowen WD. Nicholson HE, et al. Among authors: mccurdy cr. J Pharmacol Exp Ther. 2019 Feb;368(2):272-281. doi: 10.1124/jpet.118.253484. Epub 2018 Dec 7. J Pharmacol Exp Ther. 2019. PMID: 30530624 Free PMC article.
Bioanalytical method development and validation of MES207, a neuropeptide FF receptor antagonist, and its application in preclinical pharmacokinetics.
King TI, Roewekamp AC, Sharma A, Harrison S, Mesangeau C, Mottinelli M, Kamble SH, McCurdy CR, Avery BA. King TI, et al. Among authors: mccurdy cr. J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Dec 15;1134-1135:121875. doi: 10.1016/j.jchromb.2019.121875. Epub 2019 Nov 12. J Chromatogr B Analyt Technol Biomed Life Sci. 2019. PMID: 31790916 Free PMC article.
Discovery of a Highly Selective Sigma-2 Receptor Ligand, 1-(4-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-3-methyl-1H-benzo[d]imidazol-2(3H)-one (CM398), with Drug-Like Properties and Antinociceptive Effects In Vivo.
Intagliata S, Sharma A, King TI, Mesangeau C, Seminerio M, Chin FT, Wilson LL, Matsumoto RR, McLaughlin JP, Avery BA, McCurdy CR. Intagliata S, et al. Among authors: mccurdy cr. AAPS J. 2020 Jul 20;22(5):94. doi: 10.1208/s12248-020-00472-x. AAPS J. 2020. PMID: 32691179
Evaluation of 18F-IAM6067 as a sigma-1 receptor PET tracer for neurodegeneration in vivo in rodents and in human tissue.
Lepelletier FX, Vandesquille M, Asselin MC, Prenant C, Robinson AC, Mann DMA, Green M, Barnett E, Banister SD, Mottinelli M, Mesangeau C, McCurdy CR, Fricke IB, Jacobs AH, Kassiou M, Boutin H. Lepelletier FX, et al. Among authors: mccurdy cr. Theranostics. 2020 Jun 29;10(18):7938-7955. doi: 10.7150/thno.47585. eCollection 2020. Theranostics. 2020. PMID: 32724451 Free PMC article.
189 results