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Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety.
Cohen F, Aggen JB, Andrews LD, Assar Z, Boggs J, Choi T, Dozzo P, Easterday AN, Haglund CM, Hildebrandt DJ, Holt MC, Joly K, Jubb A, Kamal Z, Kane TR, Konradi AW, Krause KM, Linsell MS, Machajewski TD, Miroshnikova O, Moser HE, Nieto V, Phan T, Plato C, Serio AW, Seroogy J, Shakhmin A, Stein AJ, Sun AD, Sviridov S, Wang Z, Wlasichuk K, Yang W, Zhou X, Zhu H, Cirz RT. Cohen F, et al. Among authors: miroshnikova o. ChemMedChem. 2019 Aug 20;14(16):1560-1572. doi: 10.1002/cmdc.201900287. Epub 2019 Aug 5. ChemMedChem. 2019. PMID: 31283109
A modification of the N-terminal amino acid in the eremomycin aglycone.
Miroshnikova OV, Berdnikova TF, Olsufyeva EN, Pavlov AY, Reznikova MI, Preobrazhenskaya MN, Ciabatti R, Malabarba A, Colombo L. Miroshnikova OV, et al. J Antibiot (Tokyo). 1996 Nov;49(11):1157-61. doi: 10.7164/antibiotics.49.1157. J Antibiot (Tokyo). 1996. PMID: 8982345 Free article.
N'-(alpha-aminoacyl)- and N'-alpha-(N-alkylamino)acyl derivatives of vancomycin and eremomycin. II. Antibacterial activity of N'-(alpha-aminoacyl)- and N'-alpha-(N-alkylamino)acyl derivatives of vancomycin and eremomycin.
Plattner JJ, Chu D, Mirchink EP, Isakova EB, Preobrazhenskaya MN, Olsufyeva EN, Miroshnikova OV, Printsevskaya SS. Plattner JJ, et al. Among authors: miroshnikova ov. J Antibiot (Tokyo). 2007 Apr;60(4):245-50. doi: 10.1038/ja.2007.29. J Antibiot (Tokyo). 2007. PMID: 17456974
N'-(alpha-aminoacyl)- and N'-alpha-(N(alpha)-alkylamino)acyl derivatives of vancomycin and eremomycin. I. Synthesis of N'-(alpha-aminoacyl)- and N'-alpha-(N(alpha)-alkylamino)acyl derivatives of vancomycin and eremomycin by selective aminoacylation of the amino sugar of the disaccharide branch.
Preobrazhenskaya MN, Olsufyeva EN, Miroshnikova OV, Plattner JJ, Chu D, Printsevskaya SS. Preobrazhenskaya MN, et al. Among authors: miroshnikova ov. J Antibiot (Tokyo). 2007 Apr;60(4):235-44. doi: 10.1038/ja.2007.28. J Antibiot (Tokyo). 2007. PMID: 17456973
Structure-activity relationships in the series of eremomycin carboxamides.
Miroshnikova OV, Printsevskaya SS, Olsufyeva EN, Pavlov AY, Nilius A, Hensey-Rudloff D, Preobrazhenskaya MN. Miroshnikova OV, et al. J Antibiot (Tokyo). 2000 Mar;53(3):286-93. doi: 10.7164/antibiotics.53.286. J Antibiot (Tokyo). 2000. PMID: 10819300 Free article.
16 results