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The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF.
Vetters J, van Helden MJ, Wahlen S, Tavernier SJ, Martens A, Fayazpour F, Vergote K, Vanheerswynghels M, Deswarte K, Van Moorleghem J, De Prijck S, Takahashi N, Vandenabeele P, Boon L, van Loo G, Vivier E, Lambrecht BN, Janssens S. Vetters J, et al. Among authors: boon l. J Exp Med. 2019 Sep 2;216(9):2010-2023. doi: 10.1084/jem.20182164. Epub 2019 Jul 11. J Exp Med. 2019. PMID: 31296735 Free PMC article.
A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis.
Matmati M, Jacques P, Maelfait J, Verheugen E, Kool M, Sze M, Geboes L, Louagie E, Mc Guire C, Vereecke L, Chu Y, Boon L, Staelens S, Matthys P, Lambrecht BN, Schmidt-Supprian M, Pasparakis M, Elewaut D, Beyaert R, van Loo G. Matmati M, et al. Among authors: boon l. Nat Genet. 2011 Aug 14;43(9):908-12. doi: 10.1038/ng.874. Nat Genet. 2011. PMID: 21841782
The mucosal adjuvant cholera toxin B instructs non-mucosal dendritic cells to promote IgA production via retinoic acid and TGF-β.
Gloudemans AK, Plantinga M, Guilliams M, Willart MA, Ozir-Fazalalikhan A, van der Ham A, Boon L, Harris NL, Hammad H, Hoogsteden HC, Yazdanbakhsh M, Hendriks RW, Lambrecht BN, Smits HH. Gloudemans AK, et al. Among authors: boon l. PLoS One. 2013;8(3):e59822. doi: 10.1371/journal.pone.0059822. Epub 2013 Mar 20. PLoS One. 2013. PMID: 23527272 Free PMC article.
A pathophysiological role of PDE3 in allergic airway inflammation.
Beute J, Lukkes M, Koekoek EP, Nastiti H, Ganesh K, de Bruijn MJ, Hockman S, van Nimwegen M, Braunstahl GJ, Boon L, Lambrecht BN, Manganiello VC, Hendriks RW, KleinJan A. Beute J, et al. Among authors: boon l. JCI Insight. 2018 Jan 25;3(2):e94888. doi: 10.1172/jci.insight.94888. eCollection 2018 Jan 25. JCI Insight. 2018. PMID: 29367458 Free PMC article.
585 results