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The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF.
Vetters J, van Helden MJ, Wahlen S, Tavernier SJ, Martens A, Fayazpour F, Vergote K, Vanheerswynghels M, Deswarte K, Van Moorleghem J, De Prijck S, Takahashi N, Vandenabeele P, Boon L, van Loo G, Vivier E, Lambrecht BN, Janssens S. Vetters J, et al. Among authors: martens a. J Exp Med. 2019 Sep 2;216(9):2010-2023. doi: 10.1084/jem.20182164. Epub 2019 Jul 11. J Exp Med. 2019. PMID: 31296735 Free PMC article.
A20 inhibition of STAT1 expression in myeloid cells: a novel endogenous regulatory mechanism preventing development of enthesitis.
De Wilde K, Martens A, Lambrecht S, Jacques P, Drennan MB, Debusschere K, Govindarajan S, Coudenys J, Verheugen E, Windels F, Catrysse L, Lories R, McGonagle D, Beyaert R, van Loo G, Elewaut D. De Wilde K, et al. Among authors: martens a. Ann Rheum Dis. 2017 Mar;76(3):585-592. doi: 10.1136/annrheumdis-2016-209454. Epub 2016 Aug 22. Ann Rheum Dis. 2017. PMID: 27551052
Identification of Immune-Responsive Gene 1 (IRG1) as a Target of A20.
Van Quickelberghe E, Martens A, Goeminne LJE, Clement L, van Loo G, Gevaert K. Van Quickelberghe E, et al. Among authors: martens a. J Proteome Res. 2018 Jun 1;17(6):2182-2191. doi: 10.1021/acs.jproteome.8b00139. Epub 2018 May 11. J Proteome Res. 2018. PMID: 29733654
A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation.
Voet S, Mc Guire C, Hagemeyer N, Martens A, Schroeder A, Wieghofer P, Daems C, Staszewski O, Vande Walle L, Jordao MJC, Sze M, Vikkula HK, Demeestere D, Van Imschoot G, Scott CL, Hoste E, Gonçalves A, Guilliams M, Lippens S, Libert C, Vandenbroucke RE, Kim KW, Jung S, Callaerts-Vegh Z, Callaerts P, de Wit J, Lamkanfi M, Prinz M, van Loo G. Voet S, et al. Among authors: martens a. Nat Commun. 2018 May 23;9(1):2036. doi: 10.1038/s41467-018-04376-5. Nat Commun. 2018. PMID: 29789522 Free PMC article.
Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis.
Slowicka K, Serramito-Gómez I, Boada-Romero E, Martens A, Sze M, Petta I, Vikkula HK, De Rycke R, Parthoens E, Lippens S, Savvides SN, Wullaert A, Vereecke L, Pimentel-Muiños FX, van Loo G. Slowicka K, et al. Among authors: martens a. Nat Commun. 2019 Apr 23;10(1):1834. doi: 10.1038/s41467-019-09667-z. Nat Commun. 2019. PMID: 31015422 Free PMC article.
A20 phosphorylation controls A20 function.
Martens A, van Loo G. Martens A, et al. Nat Immunol. 2019 Oct;20(10):1261-1262. doi: 10.1038/s41590-019-0481-3. Nat Immunol. 2019. PMID: 31534239 No abstract available.
719 results