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Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach.
Anumala UR, Waaler J, Nkizinkiko Y, Ignatev A, Lazarow K, Lindemann P, Olsen PA, Murthy S, Obaji E, Majouga AG, Leonov S, von Kries JP, Lehtiö L, Krauss S, Nazaré M. Anumala UR, et al. Among authors: von kries jp. J Med Chem. 2017 Dec 28;60(24):10013-10025. doi: 10.1021/acs.jmedchem.7b00883. Epub 2017 Dec 8. J Med Chem. 2017. PMID: 29155568
Cyclin-Dependent Kinase 18 Controls Trafficking of Aquaporin-2 and Its Abundance through Ubiquitin Ligase STUB1, Which Functions as an AKAP.
Dema A, Faust D, Lazarow K, Wippich M, Neuenschwander M, Zühlke K, Geelhaar A, Pallien T, Hallscheidt E, Eichhorst J, Wiesner B, Černecká H, Popp O, Mertins P, Dittmar G, von Kries JP, Klussmann E. Dema A, et al. Among authors: von kries jp. Cells. 2020 Mar 10;9(3):673. doi: 10.3390/cells9030673. Cells. 2020. PMID: 32164329 Free PMC article.
Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity.
Wetzel C, Pifferi S, Picci C, Gök C, Hoffmann D, Bali KK, Lampe A, Lapatsina L, Fleischer R, Smith ES, Bégay V, Moroni M, Estebanez L, Kühnemund J, Walcher J, Specker E, Neuenschwander M, von Kries JP, Haucke V, Kuner R, Poulet JF, Schmoranzer J, Poole K, Lewin GR. Wetzel C, et al. Among authors: von kries jp. Nat Neurosci. 2017 Feb;20(2):209-218. doi: 10.1038/nn.4454. Epub 2016 Dec 12. Nat Neurosci. 2017. PMID: 27941788 Free article.
Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway.
Klein W, Rutz C, Eckhard J, Provinciael B, Specker E, Neuenschwander M, Kleinau G, Scheerer P, von Kries JP, Nazaré M, Vermeire K, Schülein R. Klein W, et al. Among authors: von kries jp. PLoS One. 2018 Dec 13;13(12):e0208641. doi: 10.1371/journal.pone.0208641. eCollection 2018. PLoS One. 2018. PMID: 30543669 Free PMC article.
An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells.
Schrade K, Tröger J, Eldahshan A, Zühlke K, Abdul Azeez KR, Elkins JM, Neuenschwander M, Oder A, Elkewedi M, Jaksch S, Andrae K, Li J, Fernandes J, Müller PM, Grunwald S, Marino SF, Vukićević T, Eichhorst J, Wiesner B, Weber M, Kapiloff M, Rocks O, Daumke O, Wieland T, Knapp S, von Kries JP, Klussmann E. Schrade K, et al. Among authors: von kries jp. PLoS One. 2018 Jan 26;13(1):e0191423. doi: 10.1371/journal.pone.0191423. eCollection 2018. PLoS One. 2018. PMID: 29373579 Free PMC article.
Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition.
von Kleist L, Stahlschmidt W, Bulut H, Gromova K, Puchkov D, Robertson MJ, MacGregor KA, Tomilin N, Pechstein A, Chau N, Chircop M, Sakoff J, von Kries JP, Saenger W, Kräusslich HG, Shupliakov O, Robinson PJ, McCluskey A, Haucke V. von Kleist L, et al. Among authors: von kries jp. Cell. 2011 Aug 5;146(3):471-84. doi: 10.1016/j.cell.2011.06.025. Cell. 2011. PMID: 21816279 Free article.
A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice.
Waaler J, Machon O, Tumova L, Dinh H, Korinek V, Wilson SR, Paulsen JE, Pedersen NM, Eide TJ, Machonova O, Gradl D, Voronkov A, von Kries JP, Krauss S. Waaler J, et al. Among authors: von kries jp. Cancer Res. 2012 Jun 1;72(11):2822-32. doi: 10.1158/0008-5472.CAN-11-3336. Epub 2012 Mar 22. Cancer Res. 2012. PMID: 22440753
77 results