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MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer.
Dammert MA, Brägelmann J, Olsen RR, Böhm S, Monhasery N, Whitney CP, Chalishazar MD, Tumbrink HL, Guthrie MR, Klein S, Ireland AS, Ryan J, Schmitt A, Marx A, Ozretić L, Castiglione R, Lorenz C, Jachimowicz RD, Wolf E, Thomas RK, Poirier JT, Büttner R, Sen T, Byers LA, Reinhardt HC, Letai A, Oliver TG, Sos ML. Dammert MA, et al. Among authors: wolf e. Nat Commun. 2019 Aug 2;10(1):3485. doi: 10.1038/s41467-019-11371-x. Nat Commun. 2019. PMID: 31375684 Free PMC article.
Miz1 is required to maintain autophagic flux.
Wolf E, Gebhardt A, Kawauchi D, Walz S, von Eyss B, Wagner N, Renninger C, Krohne G, Asan E, Roussel MF, Eilers M. Wolf E, et al. Nat Commun. 2013;4:2535. doi: 10.1038/ncomms3535. Nat Commun. 2013. PMID: 24088869 Free PMC article.
Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles.
Walz S, Lorenzin F, Morton J, Wiese KE, von Eyss B, Herold S, Rycak L, Dumay-Odelot H, Karim S, Bartkuhn M, Roels F, Wüstefeld T, Fischer M, Teichmann M, Zender L, Wei CL, Sansom O, Wolf E, Eilers M. Walz S, et al. Among authors: wolf e. Nature. 2014 Jul 24;511(7510):483-7. doi: 10.1038/nature13473. Epub 2014 Jul 9. Nature. 2014. PMID: 25043018 Free PMC article.
Taming of the beast: shaping Myc-dependent amplification.
Wolf E, Lin CY, Eilers M, Levens DL. Wolf E, et al. Trends Cell Biol. 2015 Apr;25(4):241-8. doi: 10.1016/j.tcb.2014.10.006. Epub 2014 Dec 1. Trends Cell Biol. 2015. PMID: 25475704 Free PMC article. Review.
Recruitment of BRCA1 limits MYCN-driven accumulation of stalled RNA polymerase.
Herold S, Kalb J, Büchel G, Ade CP, Baluapuri A, Xu J, Koster J, Solvie D, Carstensen A, Klotz C, Rodewald S, Schülein-Völk C, Dobbelstein M, Wolf E, Molenaar J, Versteeg R, Walz S, Eilers M. Herold S, et al. Among authors: wolf e. Nature. 2019 Mar;567(7749):545-549. doi: 10.1038/s41586-019-1030-9. Epub 2019 Mar 20. Nature. 2019. PMID: 30894746 Free PMC article.
MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat.
Annunziata I, van de Vlekkert D, Wolf E, Finkelstein D, Neale G, Machado E, Mosca R, Campos Y, Tillman H, Roussel MF, Andrew Weesner J, Ellen Fremuth L, Qiu X, Han MJ, Grosveld GC, d'Azzo A. Annunziata I, et al. Among authors: wolf e. Nat Commun. 2019 Aug 9;10(1):3623. doi: 10.1038/s41467-019-11568-0. Nat Commun. 2019. PMID: 31399583 Free PMC article.
A MYC-GCN2-eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer.
Schmidt S, Gay D, Uthe FW, Denk S, Paauwe M, Matthes N, Diefenbacher ME, Bryson S, Warrander FC, Erhard F, Ade CP, Baluapuri A, Walz S, Jackstadt R, Ford C, Vlachogiannis G, Valeri N, Otto C, Schülein-Völk C, Maurus K, Schmitz W, Knight JRP, Wolf E, Strathdee D, Schulze A, Germer CT, Rosenwald A, Sansom OJ, Eilers M, Wiegering A. Schmidt S, et al. Among authors: wolf e. Nat Cell Biol. 2019 Nov;21(11):1413-1424. doi: 10.1038/s41556-019-0408-0. Epub 2019 Nov 4. Nat Cell Biol. 2019. PMID: 31685988 Free PMC article.
Target gene-independent functions of MYC oncoproteins.
Baluapuri A, Wolf E, Eilers M. Baluapuri A, et al. Among authors: wolf e. Nat Rev Mol Cell Biol. 2020 May;21(5):255-267. doi: 10.1038/s41580-020-0215-2. Epub 2020 Feb 18. Nat Rev Mol Cell Biol. 2020. PMID: 32071436 Free PMC article. Review.
Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma.
Schick M, Zhang L, Maurer S, Maurer HC, Isaakaidis K, Schneider L, Patra U, Schunck K, Rohleder E, Hofstetter J, Baluapuri A, Scherger AK, Slotta-Huspenina J, Hettler F, Weber J, Engleitner T, Maresch R, Slawska J, Lewis R, Istvanffy R, Habringer S, Steiger K, Baiker A, Oostendorp RAJ, Miething C, Lenhof HP, Bassermann F, Chapuy B, Wirth M, Wolf E, Rad R, Müller S, Keller U. Schick M, et al. Among authors: wolf e. Nat Commun. 2022 Jan 12;13(1):281. doi: 10.1038/s41467-021-27704-8. Nat Commun. 2022. PMID: 35022408 Free PMC article.
2,400 results