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Successful Strategies for Mitigation of a Preclinical Signal for Phototoxicity in a DGAT1 Inhibitor.
Harrison TJ, Bauer D, Berdichevsky A, Chen X, Duvadie R, Hoogheem B, Hatsis P, Liu Q, Mao J, Miduturu V, Rocheford E, Zecri F, Zessis R, Zheng R, Zhu Q, Streeper R, Patel SJ. Harrison TJ, et al. Among authors: hatsis p. ACS Med Chem Lett. 2019 Jun 20;10(8):1128-1133. doi: 10.1021/acsmedchemlett.9b00117. eCollection 2019 Aug 8. ACS Med Chem Lett. 2019. PMID: 31413796 Free PMC article.
Development and validation of an LC-MS/MS method for the quantitative analysis of the adenosine A2a receptor antagonist NIR178 and its monohydroxy metabolite in human plasma: Application to clinical pharmacokinetics.
Heudi O, Plaud N, Aumonier C, Wu S, Hatsis P, Hurtado FK, Picard F, Winter S, Flarakos J. Heudi O, et al. Among authors: hatsis p. Biomed Chromatogr. 2020 Oct;34(10):e4909. doi: 10.1002/bmc.4909. Epub 2020 Jul 6. Biomed Chromatogr. 2020. PMID: 32485782 Clinical Trial.
Compound Property Optimization in Drug Discovery Using Quantitative Surface Sampling Micro Liquid Chromatography with Tandem Mass Spectrometry.
Chen X, Hatsis P, Judge J, Argikar UA, Ren X, Sarber J, Mansfield K, Liang G, Amaral A, Catoire A, Bentley A, Ramos L, Moench P, Hintermann S, Carcache D, Glick J, Flarakos J. Chen X, et al. Among authors: hatsis p. Anal Chem. 2016 Dec 6;88(23):11813-11820. doi: 10.1021/acs.analchem.6b03449. Epub 2016 Nov 16. Anal Chem. 2016. PMID: 27797491
Metabolic Enzyme Sulfotransferase 1A1 Is the Trigger for N-Benzyl Indole Carbinol Tumor Growth Suppression.
Rothman DM, Gao X, George E, Rasmusson T, Bhatia D, Alimov I, Wang L, Kamel A, Hatsis P, Feng Y, Tutter A, Michaud G, McDonald E 3rd, Venkatesan K, Farley D, Digan ME, Ni Y, Harbinski F, Gunduz M, Wilson CJ, Buckler A, Labow M, Tallarico J, Myer VE, Porter JA, Wang S. Rothman DM, et al. Among authors: hatsis p. Chem Biol. 2015 Sep 17;22(9):1228-37. doi: 10.1016/j.chembiol.2015.06.025. Epub 2015 Sep 10. Chem Biol. 2015. PMID: 26364931
26 results