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Oncostatin M reduces atherosclerosis development in APOE*3Leiden.CETP mice and is associated with increased survival probability in humans.
Keulen DV, Pouwer MG, Emilsson V, Matic LP, Pieterman EJ, Hedin U, Gudnason V, Jennings LL, Holmstrøm K, Nielsen BS, Pasterkamp G, Lindeman JHN, van Gool AJ, Sollewijn Gelpke MD, Princen HMG, Tempel D. Keulen DV, et al. Among authors: pouwer mg. PLoS One. 2019 Aug 28;14(8):e0221477. doi: 10.1371/journal.pone.0221477. eCollection 2019. PLoS One. 2019. PMID: 31461490 Free PMC article.
The APOE∗3-Leiden Heterozygous Glucokinase Knockout Mouse as Novel Translational Disease Model for Type 2 Diabetes, Dyslipidemia, and Diabetic Atherosclerosis.
Pouwer MG, Heinonen SE, Behrendt M, Andréasson AC, van Koppen A, Menke AL, Pieterman EJ, van den Hoek AM, Jukema JW, Leighton B, Jönsson-Rylander AC, Princen HMG. Pouwer MG, et al. J Diabetes Res. 2019 Feb 21;2019:9727952. doi: 10.1155/2019/9727952. eCollection 2019. J Diabetes Res. 2019. PMID: 30949516 Free PMC article.
The tyrosine kinase inhibitor nilotinib targets the discoidin domain receptor DDR2 in calcific aortic valve stenosis.
Carracedo M, Pawelzik SC, Artiach G, Pouwer MG, Plunde O, Saliba-Gustafsson P, Ehrenborg E, Eriksson P, Pieterman E, Stenke L, Princen HMG, Franco-Cereceda A, Bäck M. Carracedo M, et al. Among authors: pouwer mg. Br J Pharmacol. 2022 Oct;179(19):4709-4721. doi: 10.1111/bph.15911. Epub 2022 Jul 19. Br J Pharmacol. 2022. PMID: 35751904 Free PMC article.
Novel high-intensive cholesterol-lowering therapies do not ameliorate knee OA development in humanized dyslipidemic mice.
van Gemert Y, Kozijn AE, Pouwer MG, Kruisbergen NNL, van den Bosch MHJ, Blom AB, Pieterman EJ, Weinans H, Stoop R, Princen HMG, van Lent PLEM. van Gemert Y, et al. Among authors: pouwer mg. Osteoarthritis Cartilage. 2021 Sep;29(9):1314-1323. doi: 10.1016/j.joca.2021.02.570. Epub 2021 Mar 12. Osteoarthritis Cartilage. 2021. PMID: 33722697 Free article.
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