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Ex vivo screen identifies CDK12 as a metastatic vulnerability in osteosarcoma.
Bayles I, Krajewska M, Pontius WD, Saiakhova A, Morrow JJ, Bartels C, Lu J, Faber ZJ, Fedorov Y, Hong ES, Karnuta JM, Rubin B, Adams DJ, George RE, Scacheri PC. Bayles I, et al. Among authors: adams dj. J Clin Invest. 2019 Oct 1;129(10):4377-4392. doi: 10.1172/JCI127718. J Clin Invest. 2019. PMID: 31498151 Free PMC article.
Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination.
Hubler Z, Allimuthu D, Bederman I, Elitt MS, Madhavan M, Allan KC, Shick HE, Garrison E, T Karl M, Factor DC, Nevin ZS, Sax JL, Thompson MA, Fedorov Y, Jin J, Wilson WK, Giera M, Bracher F, Miller RH, Tesar PJ, Adams DJ. Hubler Z, et al. Among authors: adams dj. Nature. 2018 Aug;560(7718):372-376. doi: 10.1038/s41586-018-0360-3. Epub 2018 Jul 25. Nature. 2018. PMID: 30046109 Free PMC article.
A miRNA-Mediated Approach to Dissect the Complexity of Tumor-Initiating Cell Function and Identify miRNA-Targeting Drugs.
Belur Nagaraj A, Joseph P, Ponting E, Fedorov Y, Singh S, Cole A, Lee W, Yoon E, Baccarini A, Scacheri P, Buckanovich R, Adams DJ, Drapkin R, Brown BD, DiFeo A. Belur Nagaraj A, et al. Among authors: adams dj. Stem Cell Reports. 2019 Jan 8;12(1):122-134. doi: 10.1016/j.stemcr.2018.12.002. Stem Cell Reports. 2019. PMID: 30629937 Free PMC article.
Cell Type-Specific Intralocus Interactions Reveal Oligodendrocyte Mechanisms in MS.
Factor DC, Barbeau AM, Allan KC, Hu LR, Madhavan M, Hoang AT, Hazel KEA, Hall PA, Nisraiyya S, Najm FJ, Miller TE, Nevin ZS, Karl RT, Lima BR, Song Y, Sibert AG, Dhillon GK, Volsko C, Bartels CF, Adams DJ, Dutta R, Gallagher MD, Phu W, Kozlenkov A, Dracheva S, Scacheri PC, Tesar PJ, Corradin O. Factor DC, et al. Among authors: adams dj. Cell. 2020 Apr 16;181(2):382-395.e21. doi: 10.1016/j.cell.2020.03.002. Epub 2020 Apr 3. Cell. 2020. PMID: 32246942 Free PMC article.
Targeting the chromatin binding of exportin-1 disrupts NFAT and T cell activation.
Chen YF, Ghazala M, Friedrich RM, Cordova BA, Petroze FN, Srinivasan R, Allan KC, Yan DF, Sax JL, Carr K, Tomchuck SL, Fedorov Y, Huang AY, Desai AB, Adams DJ. Chen YF, et al. Among authors: adams dj. Nat Chem Biol. 2024 Mar 25. doi: 10.1038/s41589-024-01586-5. Online ahead of print. Nat Chem Biol. 2024. PMID: 38528120
1,147 results