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An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia.
Sehgal A, Barros S, Ivanciu L, Cooley B, Qin J, Racie T, Hettinger J, Carioto M, Jiang Y, Brodsky J, Prabhala H, Zhang X, Attarwala H, Hutabarat R, Foster D, Milstein S, Charisse K, Kuchimanchi S, Maier MA, Nechev L, Kandasamy P, Kel'in AV, Nair JK, Rajeev KG, Manoharan M, Meyers R, Sorensen B, Simon AR, Dargaud Y, Negrier C, Camire RM, Akinc A. Sehgal A, et al. Nat Med. 2015 May;21(5):492-7. doi: 10.1038/nm.3847. Epub 2015 Apr 13. Nat Med. 2015. PMID: 25849132
Neutrophils and neutrophil extracellular traps enhance venous thrombosis in mice bearing human pancreatic tumors.
Hisada Y, Grover SP, Maqsood A, Houston R, Ay C, Noubouossie DF, Cooley BC, Wallén H, Key NS, Thålin C, Farkas ÁZ, Farkas VJ, Tenekedjiev K, Kolev K, Mackman N. Hisada Y, et al. Among authors: cooley bc. Haematologica. 2020 Jan;105(1):218-225. doi: 10.3324/haematol.2019.217083. Epub 2019 May 2. Haematologica. 2020. PMID: 31048354 Free PMC article.
Elevated prothrombin promotes venous, but not arterial, thrombosis in mice.
Aleman MM, Walton BL, Byrnes JR, Wang JG, Heisler MJ, Machlus KR, Cooley BC, Wolberg AS. Aleman MM, et al. Among authors: cooley bc. Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1829-36. doi: 10.1161/ATVBAHA.113.301607. Epub 2013 May 30. Arterioscler Thromb Vasc Biol. 2013. PMID: 23723374 Free PMC article.
137 results