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Pyroglutamide-Based P2X7 Receptor Antagonists Targeting Inflammatory Bowel Disease.
Homerin G, Jawhara S, Dezitter X, Baudelet D, Dufrénoy P, Rigo B, Millet R, Furman C, Ragé G, Lipka E, Farce A, Renault N, Sendid B, Charlet R, Leroy J, Phanithavong M, Richeval C, Wiart JF, Allorge D, Adriouch S, Vouret-Craviari V, Ghinet A. Homerin G, et al. Among authors: vouret craviari v. J Med Chem. 2020 Mar 12;63(5):2074-2094. doi: 10.1021/acs.jmedchem.9b00584. Epub 2019 Sep 27. J Med Chem. 2020. PMID: 31525963
A small-molecule P2RX7 activator promotes anti-tumor immune responses and sensitizes lung tumor to immunotherapy.
Douguet L, Janho Dit Hreich S, Benzaquen J, Seguin L, Juhel T, Dezitter X, Duranton C, Ryffel B, Kanellopoulos J, Delarasse C, Renault N, Furman C, Homerin G, Féral C, Cherfils-Vicini J, Millet R, Adriouch S, Ghinet A, Hofman P, Vouret-Craviari V. Douguet L, et al. Among authors: vouret craviari v. Nat Commun. 2021 Jan 28;12(1):653. doi: 10.1038/s41467-021-20912-2. Nat Commun. 2021. PMID: 33510147 Free PMC article.
The Role of IL-18 in P2RX7-Mediated Antitumor Immunity.
Janho Dit Hreich S, Hofman P, Vouret-Craviari V. Janho Dit Hreich S, et al. Among authors: vouret craviari v. Int J Mol Sci. 2023 May 25;24(11):9235. doi: 10.3390/ijms24119235. Int J Mol Sci. 2023. PMID: 37298187 Free PMC article. Review.
Amplification loop of the inflammatory process is induced by P2X7R activation in intestinal epithelial cells in response to neutrophil transepithelial migration.
Cesaro A, Brest P, Hofman V, Hébuterne X, Wildman S, Ferrua B, Marchetti S, Doglio A, Vouret-Craviari V, Galland F, Naquet P, Mograbi B, Unwin R, Hofman P. Cesaro A, et al. Am J Physiol Gastrointest Liver Physiol. 2010 Jul;299(1):G32-42. doi: 10.1152/ajpgi.00282.2009. Epub 2010 Feb 25. Am J Physiol Gastrointest Liver Physiol. 2010. PMID: 20185692 Free article.
47 results