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Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome.
Labuhn M, Perkins K, Matzk S, Varghese L, Garnett C, Papaemmanuil E, Metzner M, Kennedy A, Amstislavskiy V, Risch T, Bhayadia R, Samulowski D, Hernandez DC, Stoilova B, Iotchkova V, Oppermann U, Scheer C, Yoshida K, Schwarzer A, Taub JW, Crispino JD, Weiss MJ, Hayashi Y, Taga T, Ito E, Ogawa S, Reinhardt D, Yaspo ML, Campbell PJ, Roberts I, Constantinescu SN, Vyas P, Heckl D, Klusmann JH. Labuhn M, et al. Among authors: varghese l. Cancer Cell. 2019 Sep 16;36(3):340. doi: 10.1016/j.ccell.2019.08.014. Cancer Cell. 2019. PMID: 31526763 Free article. No abstract available.
Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome.
Labuhn M, Perkins K, Matzk S, Varghese L, Garnett C, Papaemmanuil E, Metzner M, Kennedy A, Amstislavskiy V, Risch T, Bhayadia R, Samulowski D, Hernandez DC, Stoilova B, Iotchkova V, Oppermann U, Scheer C, Yoshida K, Schwarzer A, Taub JW, Crispino JD, Weiss MJ, Hayashi Y, Taga T, Ito E, Ogawa S, Reinhardt D, Yaspo ML, Campbell PJ, Roberts I, Constantinescu SN, Vyas P, Heckl D, Klusmann JH. Labuhn M, et al. Among authors: varghese l. Cancer Cell. 2019 Aug 12;36(2):123-138.e10. doi: 10.1016/j.ccell.2019.06.007. Epub 2019 Jul 11. Cancer Cell. 2019. PMID: 31303423 Free PMC article.
MPL membrane domain sequencing goes deep.
Constantinescu SN, Varghese LN. Constantinescu SN, et al. Blood. 2020 Jan 23;135(4):236-237. doi: 10.1182/blood.2019003482. Blood. 2020. PMID: 31972012 Free article. No abstract available.
MPL S505C enhances driver mutations at W515 in essential thrombocythemia.
Varghese LN, Carreño-Tarragona G, Levy G, Gutiérrez-López de Ocáriz X, Rapado I, Martínez-López J, Ayala R, Constantinescu SN. Varghese LN, et al. Blood Cancer J. 2021 Nov 29;11(11):188. doi: 10.1038/s41408-021-00583-4. Blood Cancer J. 2021. PMID: 34845187 Free PMC article. No abstract available.
A typical acute lymphoblastic leukemia JAK2 variant, R683G, causes an aggressive form of familial thrombocytosis when germline.
Carreño-Tarragona G, Varghese LN, Sebastián E, Gálvez E, Marín-Sánchez A, López-Muñoz N, Nam-Cha S, Martínez-López J, Constantinescu SN, Sevilla J, Ayala R. Carreño-Tarragona G, et al. Leukemia. 2021 Nov;35(11):3295-3298. doi: 10.1038/s41375-021-01239-9. Epub 2021 Apr 12. Leukemia. 2021. PMID: 33846542 No abstract available.
An incomplete trafficking defect to the cell-surface leads to paradoxical thrombocytosis for human and murine MPL P106L.
Favale F, Messaoudi K, Varghese LN, Boukour S, Pecquet C, Gryshkova V, Defour JP, Albu RI, Bluteau O, Ballerini P, Leverger G, Plo I, Debili N, Raslova H, Favier R, Constantinescu SN, Vainchenker W. Favale F, et al. Blood. 2016 Dec 29;128(26):3146-3158. doi: 10.1182/blood-2016-06-722058. Epub 2016 Nov 10. Blood. 2016. PMID: 28034873 Free article.
226 results