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Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification.
Santos MCFD, Anderson CP, Neschen S, Zumbrennen-Bullough KB, Romney SJ, Kahle-Stephan M, Rathkolb B, Gailus-Durner V, Fuchs H, Wolf E, Rozman J, de Angelis MH, Cai WM, Rajan M, Hu J, Dedon PC, Leibold EA. Santos MCFD, et al. Among authors: romney sj. Nat Commun. 2020 Jan 15;11(1):296. doi: 10.1038/s41467-019-14004-5. Nat Commun. 2020. PMID: 31941883 Free PMC article.
Abnormal brain iron metabolism in Irp2 deficient mice is associated with mild neurological and behavioral impairments.
Zumbrennen-Bullough KB, Becker L, Garrett L, Hölter SM, Calzada-Wack J, Mossbrugger I, Quintanilla-Fend L, Racz I, Rathkolb B, Klopstock T, Wurst W, Zimmer A, Wolf E, Fuchs H, Gailus-Durner V, de Angelis MH, Romney SJ, Leibold EA. Zumbrennen-Bullough KB, et al. Among authors: romney sj. PLoS One. 2014 Jun 4;9(6):e98072. doi: 10.1371/journal.pone.0098072. eCollection 2014. PLoS One. 2014. PMID: 24896637 Free PMC article.