Hook V - Search Results

1

Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and Trypanosoma cruzi Cruzain.

Boudreau PD, Miller BW, McCall LI, Almaliti J, Reher R, Hirata K, Le T, Siqueira-Neto JL, Hook V, Gerwick WH. Boudreau PD, et al. Among authors: hook v. J Med Chem. 2019 Oct 24;62(20):9026-9044. doi: 10.1021/acs.jmedchem.9b00294. Epub 2019 Oct 4. J Med Chem. 2019. PMID: 31539239 Free PMC article.

2

Inhibition of cathepsin B reduces beta-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate beta-secretase of Alzheimer's disease.

Hook V, Toneff T, Bogyo M, Greenbaum D, Medzihradszky KF, Neveu J, Lane W, Hook G, Reisine T. Hook V, et al. Among authors: hook g. Biol Chem. 2005 Sep;386(9):931-40. doi: 10.1515/BC.2005.108. Biol Chem. 2005. PMID: 16164418

3

Unique neuronal functions of cathepsin L and cathepsin B in secretory vesicles: biosynthesis of peptides in neurotransmission and neurodegenerative disease.

Hook VY. Hook VY. Biol Chem. 2006 Oct-Nov;387(10-11):1429-39. doi: 10.1515/BC.2006.179. Biol Chem. 2006. PMID: 17081116 Review.

4

Cysteine protease inhibitors effectively reduce in vivo levels of brain beta-amyloid related to Alzheimer's disease.

Hook V, Kindy M, Hook G. Hook V, et al. Among authors: hook g. Biol Chem. 2007 Feb;388(2):247-52. doi: 10.1515/BC.2007.027. Biol Chem. 2007. PMID: 17261088

5

Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein.

Hook VY, Kindy M, Hook G. Hook VY, et al. J Biol Chem. 2008 Mar 21;283(12):7745-53. doi: 10.1074/jbc.M708362200. Epub 2008 Jan 9. J Biol Chem. 2008. PMID: 18184658 Free article.

6

Pharmacogenetic features of cathepsin B inhibitors that improve memory deficit and reduce beta-amyloid related to Alzheimer's disease.

Hook V, Hook G, Kindy M. Hook V, et al. Among authors: hook g. Biol Chem. 2010 Aug;391(8):861-72. doi: 10.1515/BC.2010.110. Biol Chem. 2010. PMID: 20536395 Free PMC article. Review.

7

The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L.

Miller B, Friedman AJ, Choi H, Hogan J, McCammon JA, Hook V, Gerwick WH. Miller B, et al. Among authors: hook v. J Nat Prod. 2014 Jan 24;77(1):92-9. doi: 10.1021/np400727r. Epub 2013 Dec 23. J Nat Prod. 2014. PMID: 24364476 Free PMC article.

8

Mass Spectrometry-Based Visualization of Molecules Associated with Human Habitats.

Petras D, Nothias LF, Quinn RA, Alexandrov T, Bandeira N, Bouslimani A, Castro-Falcón G, Chen L, Dang T, Floros DJ, Hook V, Garg N, Hoffner N, Jiang Y, Kapono CA, Koester I, Knight R, Leber CA, Ling TJ, Luzzatto-Knaan T, McCall LI, McGrath AP, Meehan MJ, Merritt JK, Mills RH, Morton J, Podvin S, Protsyuk I, Purdy T, Satterfield K, Searles S, Shah S, Shires S, Steffen D, White M, Todoric J, Tuttle R, Wojnicz A, Sapp V, Vargas F, Yang J, Zhang C, Dorrestein PC. Petras D, et al. Among authors: hook v. Anal Chem. 2016 Nov 15;88(22):10775-10784. doi: 10.1021/acs.analchem.6b03456. Epub 2016 Oct 24. Anal Chem. 2016. PMID: 27732780 Free PMC article.

9

The Proteasome as a Drug Target in the Metazoan Pathogen, Schistosoma mansoni.

Bibo-Verdugo B, Wang SC, Almaliti J, Ta AP, Jiang Z, Wong DA, Lietz CB, Suzuki BM, El-Sakkary N, Hook V, Salvesen GS, Gerwick WH, Caffrey CR, O'Donoghue AJ. Bibo-Verdugo B, et al. Among authors: hook v. ACS Infect Dis. 2019 Oct 11;5(10):1802-1812. doi: 10.1021/acsinfecdis.9b00237. Epub 2019 Aug 12. ACS Infect Dis. 2019. PMID: 31355632 Free PMC article.

10

Potent in vitro anti-SARS-CoV-2 activity by gallinamide A and analogues via inhibition of cathepsin L.

Ashhurst AS, Tang AH, Fajtová P, Yoon M, Aggarwal A, Stoye A, Larance M, Beretta L, Drelich A, Skinner D, Li L, Meek TD, McKerrow JH, Hook V, Tseng CK, Turville S, Gerwick WH, O'Donoghue AJ, Payne RJ. Ashhurst AS, et al. Among authors: hook v. bioRxiv [Preprint]. 2020 Dec 24:2020.12.23.424111. doi: 10.1101/2020.12.23.424111. bioRxiv. 2020. PMID: 33398273 Free PMC article. Updated. Preprint.

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