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Page 1
Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease.
Hickson LJ, Langhi Prata LGP, Bobart SA, Evans TK, Giorgadze N, Hashmi SK, Herrmann SM, Jensen MD, Jia Q, Jordan KL, Kellogg TA, Khosla S, Koerber DM, Lagnado AB, Lawson DK, LeBrasseur NK, Lerman LO, McDonald KM, McKenzie TJ, Passos JF, Pignolo RJ, Pirtskhalava T, Saadiq IM, Schaefer KK, Textor SC, Victorelli SG, Volkman TL, Xue A, Wentworth MA, Wissler Gerdes EO, Zhu Y, Tchkonia T, Kirkland JL. Hickson LJ, et al. Among authors: giorgadze n. EBioMedicine. 2019 Sep;47:446-456. doi: 10.1016/j.ebiom.2019.08.069. Epub 2019 Sep 18. EBioMedicine. 2019. PMID: 31542391 Free PMC article.
Fat depot origin affects adipogenesis in primary cultured and cloned human preadipocytes.
Tchkonia T, Giorgadze N, Pirtskhalava T, Tchoukalova Y, Karagiannides I, Forse RA, DePonte M, Stevenson M, Guo W, Han J, Waloga G, Lash TL, Jensen MD, Kirkland JL. Tchkonia T, et al. Among authors: giorgadze n. Am J Physiol Regul Integr Comp Physiol. 2002 May;282(5):R1286-96. doi: 10.1152/ajpregu.00653.2001. Am J Physiol Regul Integr Comp Physiol. 2002. PMID: 11959668 Free article.
Abundance of two human preadipocyte subtypes with distinct capacities for replication, adipogenesis, and apoptosis varies among fat depots.
Tchkonia T, Tchoukalova YD, Giorgadze N, Pirtskhalava T, Karagiannides I, Forse RA, Koo A, Stevenson M, Chinnappan D, Cartwright A, Jensen MD, Kirkland JL. Tchkonia T, et al. Among authors: giorgadze n. Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E267-77. doi: 10.1152/ajpendo.00265.2004. Epub 2004 Sep 21. Am J Physiol Endocrinol Metab. 2005. PMID: 15383371 Free article.
Sex- and depot-dependent differences in adipogenesis in normal-weight humans.
Tchoukalova YD, Koutsari C, Votruba SB, Tchkonia T, Giorgadze N, Thomou T, Kirkland JL, Jensen MD. Tchoukalova YD, et al. Among authors: giorgadze n. Obesity (Silver Spring). 2010 Oct;18(10):1875-80. doi: 10.1038/oby.2010.56. Epub 2010 Mar 18. Obesity (Silver Spring). 2010. PMID: 20300084 Free PMC article.
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.
Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, Palmer AK, Ikeno Y, Hubbard GB, Lenburg M, O'Hara SP, LaRusso NF, Miller JD, Roos CM, Verzosa GC, LeBrasseur NK, Wren JD, Farr JN, Khosla S, Stout MB, McGowan SJ, Fuhrmann-Stroissnigg H, Gurkar AU, Zhao J, Colangelo D, Dorronsoro A, Ling YY, Barghouthy AS, Navarro DC, Sano T, Robbins PD, Niedernhofer LJ, Kirkland JL. Zhu Y, et al. Among authors: giorgadze n. Aging Cell. 2015 Aug;14(4):644-58. doi: 10.1111/acel.12344. Epub 2015 Apr 22. Aging Cell. 2015. PMID: 25754370 Free PMC article.
Inflammation and the depot-specific secretome of human preadipocytes.
Zhu Y, Tchkonia T, Stout MB, Giorgadze N, Wang L, Li PW, Heppelmann CJ, Bouloumié A, Jensen MD, Bergen HR 3rd, Kirkland JL. Zhu Y, et al. Among authors: giorgadze n. Obesity (Silver Spring). 2015 May;23(5):989-99. doi: 10.1002/oby.21053. Epub 2015 Apr 10. Obesity (Silver Spring). 2015. PMID: 25864718 Free PMC article.
Pathogenesis of pancreatic cancer exosome-induced lipolysis in adipose tissue.
Sagar G, Sah RP, Javeed N, Dutta SK, Smyrk TC, Lau JS, Giorgadze N, Tchkonia T, Kirkland JL, Chari ST, Mukhopadhyay D. Sagar G, et al. Among authors: giorgadze n. Gut. 2016 Jul;65(7):1165-74. doi: 10.1136/gutjnl-2014-308350. Epub 2015 Apr 28. Gut. 2016. PMID: 26061593 Free PMC article.
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age.
Xu M, Tchkonia T, Ding H, Ogrodnik M, Lubbers ER, Pirtskhalava T, White TA, Johnson KO, Stout MB, Mezera V, Giorgadze N, Jensen MD, LeBrasseur NK, Kirkland JL. Xu M, et al. Among authors: giorgadze n. Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):E6301-10. doi: 10.1073/pnas.1515386112. Epub 2015 Nov 2. Proc Natl Acad Sci U S A. 2015. PMID: 26578790 Free PMC article.
36 results