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The pyrrolizidine alkaloid senecionine induces CYP-dependent destruction of sinusoidal endothelial cells and cholestasis in mice.
Arch Toxicol. 2020 Jan;94(1):219-229. doi: 10.1007/s00204-019-02582-8. Epub 2019 Oct 12.
Arch Toxicol. 2020.
PMID: 31606820
Active Transport of Hepatotoxic Pyrrolizidine Alkaloids in HepaRG Cells.
Enge AM, Kaltner F, Gottschalk C, Braeuning A, Hessel-Pras S.
Enge AM, et al.
Int J Mol Sci. 2021 Apr 7;22(8):3821. doi: 10.3390/ijms22083821.
Int J Mol Sci. 2021.
PMID: 33917053
Free PMC article.
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Organic Cation Transporter I and Na+ /taurocholate Co-Transporting Polypeptide are Involved in Retrorsine- and Senecionine-Induced Hepatotoxicity in HepaRG cells.
Enge AM, Kaltner F, Gottschalk C, Kin A, Kirstgen M, Geyer J, These A, Hammer H, Pötz O, Braeuning A, Hessel-Pras S.
Enge AM, et al.
Mol Nutr Food Res. 2022 Jan;66(2):e2100800. doi: 10.1002/mnfr.202100800. Epub 2021 Dec 11.
Mol Nutr Food Res. 2022.
PMID: 34826203
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Identification of microRNAs Implicated in Modulating Senecionine-Induced Liver Toxicity in HepaRG Cells.
Enge AM, Sprenger H, Braeuning A, Hessel-Pras S.
Enge AM, et al.
Foods. 2022 Feb 12;11(4):532. doi: 10.3390/foods11040532.
Foods. 2022.
PMID: 35206009
Free PMC article.
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The chemical structure impairs the intensity of genotoxic effects promoted by 1,2-unsaturated pyrrolizidine alkaloids in vitro.
Buchmueller J, Enge AM, Peters A, Ebmeyer J, Küpper JH, Schäfer B, Braeuning A, Hessel-Pras S.
Buchmueller J, et al. Among authors: enge am.
Food Chem Toxicol. 2022 Jun;164:113049. doi: 10.1016/j.fct.2022.113049. Epub 2022 Apr 30.
Food Chem Toxicol. 2022.
PMID: 35500694
Free article.
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PBTK model-based analysis of CYP3A4 induction and the toxicokinetics of the pyrrolizidine alkaloid retrorsine in man.
Lehmann A, Geburek I, Hessel-Pras S, Enge AM, Mielke H, Müller-Graf C, Kloft C, Hethey C.
Lehmann A, et al. Among authors: enge am.
Arch Toxicol. 2024 Jun;98(6):1757-1769. doi: 10.1007/s00204-024-03698-2. Epub 2024 Mar 25.
Arch Toxicol. 2024.
PMID: 38528153
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