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From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.
Cell Chem Biol. 2020 Jan 16;27(1):32-40.e3. doi: 10.1016/j.chembiol.2019.10.002. Epub 2019 Oct 22.
Cell Chem Biol. 2020.
PMID: 31653597
Free article.
From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.
Petrilli WL, Adam GC, Erdmann RS, Abeywickrema P, Agnani V, Ai X, Baysarowich J, Byrne N, Caldwell JP, Chang W, DiNunzio E, Feng Z, Ford R, Ha S, Huang Y, Hubbard B, Johnston JM, Kavana M, Lisnock JM, Liang R, Lu J, Lu Z, Meng J, Orth P, Palyha O, Parthasarathy G, Salowe SP, Sharma S, Shipman J, Soisson SM, Strack A, Youm H, Zhao K, Zink DL, Zokian H, Addona GH, Akinsanya K, Tata JR, Xiong Y, Imbriglio JE.
Petrilli WL, et al. Among authors: baysarowich j.
Cell Chem Biol. 2021 Feb 18;28(2):243. doi: 10.1016/j.chembiol.2021.01.019.
Cell Chem Biol. 2021.
PMID: 33607006
Free article.
No abstract available.
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PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain.
Liu M, Wu G, Baysarowich J, Kavana M, Addona GH, Bierilo KK, Mudgett JS, Pavlovic G, Sitlani A, Renger JJ, Hubbard BK, Fisher TS, Zerbinatti CV.
Liu M, et al. Among authors: baysarowich j.
J Lipid Res. 2010 Sep;51(9):2611-8. doi: 10.1194/jlr.M006635. Epub 2010 May 7.
J Lipid Res. 2010.
PMID: 20453200
Free PMC article.
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Structural and biochemical characterization of the wild type PCSK9-EGF(AB) complex and natural familial hypercholesterolemia mutants.
Bottomley MJ, Cirillo A, Orsatti L, Ruggeri L, Fisher TS, Santoro JC, Cummings RT, Cubbon RM, Lo Surdo P, Calzetta A, Noto A, Baysarowich J, Mattu M, Talamo F, De Francesco R, Sparrow CP, Sitlani A, Carfí A.
Bottomley MJ, et al. Among authors: baysarowich j.
J Biol Chem. 2009 Jan 9;284(2):1313-23. doi: 10.1074/jbc.M808363200. Epub 2008 Nov 10.
J Biol Chem. 2009.
PMID: 19001363
Free article.
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Rifamycin antibiotic resistance by ADP-ribosylation: Structure and diversity of Arr.
Baysarowich J, Koteva K, Hughes DW, Ejim L, Griffiths E, Zhang K, Junop M, Wright GD.
Baysarowich J, et al.
Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4886-91. doi: 10.1073/pnas.0711939105. Epub 2008 Mar 18.
Proc Natl Acad Sci U S A. 2008.
PMID: 18349144
Free PMC article.
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