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Page 1
Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain.
Van Steenwinckel J, Schang AL, Krishnan ML, Degos V, Delahaye-Duriez A, Bokobza C, Csaba Z, Verdonk F, Montané A, Sigaut S, Hennebert O, Lebon S, Schwendimann L, Le Charpentier T, Hassan-Abdi R, Ball G, Aljabar P, Saxena A, Holloway RK, Birchmeier W, Baud O, Rowitch D, Miron V, Chretien F, Leconte C, Besson VC, Petretto EG, Edwards AD, Hagberg H, Soussi-Yanicostas N, Fleiss B, Gressens P. Van Steenwinckel J, et al. Among authors: petretto eg. Brain. 2019 Dec 1;142(12):3806-3833. doi: 10.1093/brain/awz319. Brain. 2019. PMID: 31665242 Free PMC article.
Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus.
Johnson MR, Behmoaras J, Bottolo L, Krishnan ML, Pernhorst K, Santoscoy PLM, Rossetti T, Speed D, Srivastava PK, Chadeau-Hyam M, Hajji N, Dabrowska A, Rotival M, Razzaghi B, Kovac S, Wanisch K, Grillo FW, Slaviero A, Langley SR, Shkura K, Roncon P, De T, Mattheisen M, Niehusmann P, O'Brien TJ, Petrovski S, von Lehe M, Hoffmann P, Eriksson J, Coffey AJ, Cichon S, Walker M, Simonato M, Danis B, Mazzuferi M, Foerch P, Schoch S, De Paola V, Kaminski RM, Cunliffe VT, Becker AJ, Petretto E. Johnson MR, et al. Nat Commun. 2015 Jan 23;6:6031. doi: 10.1038/ncomms7031. Nat Commun. 2015. PMID: 25615886 Free PMC article.
Rare and common epilepsies converge on a shared gene regulatory network providing opportunities for novel antiepileptic drug discovery.
Delahaye-Duriez A, Srivastava P, Shkura K, Langley SR, Laaniste L, Moreno-Moral A, Danis B, Mazzuferi M, Foerch P, Gazina EV, Richards K, Petrou S, Kaminski RM, Petretto E, Johnson MR. Delahaye-Duriez A, et al. Genome Biol. 2016 Dec 13;17(1):245. doi: 10.1186/s13059-016-1097-7. Genome Biol. 2016. PMID: 27955713 Free PMC article.
Integrative genomics of microglia implicates DLG4 (PSD95) in the white matter development of preterm infants.
Krishnan ML, Van Steenwinckel J, Schang AL, Yan J, Arnadottir J, Le Charpentier T, Csaba Z, Dournaud P, Cipriani S, Auvynet C, Titomanlio L, Pansiot J, Ball G, Boardman JP, Walley AJ, Saxena A, Mirza G, Fleiss B, Edwards AD, Petretto E, Gressens P. Krishnan ML, et al. Nat Commun. 2017 Sep 5;8(1):428. doi: 10.1038/s41467-017-00422-w. Nat Commun. 2017. PMID: 28874660 Free PMC article.
A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target.
Srivastava PK, van Eyll J, Godard P, Mazzuferi M, Delahaye-Duriez A, Van Steenwinckel J, Gressens P, Danis B, Vandenplas C, Foerch P, Leclercq K, Mairet-Coello G, Cardenas A, Vanclef F, Laaniste L, Niespodziany I, Keaney J, Gasser J, Gillet G, Shkura K, Chong SA, Behmoaras J, Kadiu I, Petretto E, Kaminski RM, Johnson MR. Srivastava PK, et al. Nat Commun. 2018 Sep 3;9(1):3561. doi: 10.1038/s41467-018-06008-4. Nat Commun. 2018. PMID: 30177815 Free PMC article.
Integrated systems-genetic analyses reveal a network target for delaying glioma progression.
Laaniste L, Srivastava PK, Stylianou J, Syed N, Cases-Cunillera S, Shkura K, Zeng Q, Rackham OJL, Langley SR, Delahaye-Duriez A, O'Neill K, Williams M, Becker A, Roncaroli F, Petretto E, Johnson MR. Laaniste L, et al. Ann Clin Transl Neurol. 2019 Sep;6(9):1616-1638. doi: 10.1002/acn3.50850. Epub 2019 Aug 17. Ann Clin Transl Neurol. 2019. PMID: 31420939 Free PMC article.
Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease.
Johnson MR, Shkura K, Langley SR, Delahaye-Duriez A, Srivastava P, Hill WD, Rackham OJ, Davies G, Harris SE, Moreno-Moral A, Rotival M, Speed D, Petrovski S, Katz A, Hayward C, Porteous DJ, Smith BH, Padmanabhan S, Hocking LJ, Starr JM, Liewald DC, Visconti A, Falchi M, Bottolo L, Rossetti T, Danis B, Mazzuferi M, Foerch P, Grote A, Helmstaedter C, Becker AJ, Kaminski RM, Deary IJ, Petretto E. Johnson MR, et al. Nat Neurosci. 2016 Feb;19(2):223-32. doi: 10.1038/nn.4205. Epub 2015 Dec 21. Nat Neurosci. 2016. PMID: 26691832 Free article.
Genome-wide analysis of differential RNA editing in epilepsy.
Srivastava PK, Bagnati M, Delahaye-Duriez A, Ko JH, Rotival M, Langley SR, Shkura K, Mazzuferi M, Danis B, van Eyll J, Foerch P, Behmoaras J, Kaminski RM, Petretto E, Johnson MR. Srivastava PK, et al. Genome Res. 2017 Mar;27(3):440-450. doi: 10.1101/gr.210740.116. Genome Res. 2017. PMID: 28250018 Free PMC article.
130 results