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DNA-bound elastase of neutrophil extracellular traps degrades plasminogen, reduces plasmin formation, and decreases fibrinolysis: proof of concept in septic shock plasma.
Cruz DBD, Helms J, Aquino LR, Stiel L, Cougourdan L, Broussard C, Chafey P, Riès-Kautt M, Meziani F, Toti F, Gaussem P, Anglés-Cano E. Cruz DBD, et al. Among authors: helms j. FASEB J. 2019 Dec;33(12):14270-14280. doi: 10.1096/fj.201901363RRR. Epub 2019 Nov 4. FASEB J. 2019. PMID: 31682515
In conclusion, we show that NETs bearing active HNE-DNA complexes reduce plasminogen into fragments, thus impairing fibrinolysis by decreasing the local plasminogen concentration, plasminogen binding to fibrin, and localized plasmin formation.-Barbosa da Cruz, D., Helms, …
In conclusion, we show that NETs bearing active HNE-DNA complexes reduce plasminogen into fragments, thus impairing fibrinolysis by decreasi …
Neutrophil Activation During Septic Shock.
Stiel L, Meziani F, Helms J. Stiel L, et al. Among authors: helms j. Shock. 2018 Apr;49(4):371-384. doi: 10.1097/SHK.0000000000000980. Shock. 2018. PMID: 28858142 Review.
Immunohaemostasis: a new view on haemostasis during sepsis.
Delabranche X, Helms J, Meziani F. Delabranche X, et al. Among authors: helms j. Ann Intensive Care. 2017 Dec 2;7(1):117. doi: 10.1186/s13613-017-0339-5. Ann Intensive Care. 2017. PMID: 29197958 Free PMC article. Review.
Vertebral fracture as a complication of cardiopulmonary resuscitation.
Merdji H, Poussardin C, Helms J, Meziani F. Merdji H, et al. Among authors: helms j. Intensive Care Med. 2018 Oct;44(10):1750-1751. doi: 10.1007/s00134-018-5170-4. Epub 2018 Apr 23. Intensive Care Med. 2018. PMID: 29687321 No abstract available.
Out of the ICU shifting as a significant workload.
Merdji H, Clere-Jehl R, Dargent A, Andreu P, Large A, Lefebvre F, Schenck M, Helms J, Quenot JP, Meziani F. Merdji H, et al. Among authors: helms j. Intensive Care Med. 2018 Sep;44(9):1582-1583. doi: 10.1007/s00134-018-5240-7. Epub 2018 Jun 13. Intensive Care Med. 2018. PMID: 29947882 No abstract available.
Timing of Renal-Replacement Therapy in Patients with Acute Kidney Injury and Sepsis.
Barbar SD, Clere-Jehl R, Bourredjem A, Hernu R, Montini F, Bruyère R, Lebert C, Bohé J, Badie J, Eraldi JP, Rigaud JP, Levy B, Siami S, Louis G, Bouadma L, Constantin JM, Mercier E, Klouche K, du Cheyron D, Piton G, Annane D, Jaber S, van der Linden T, Blasco G, Mira JP, Schwebel C, Chimot L, Guiot P, Nay MA, Meziani F, Helms J, Roger C, Louart B, Trusson R, Dargent A, Binquet C, Quenot JP; IDEAL-ICU Trial Investigators and the CRICS TRIGGERSEP Network. Barbar SD, et al. Among authors: helms j. N Engl J Med. 2018 Oct 11;379(15):1431-1442. doi: 10.1056/NEJMoa1803213. N Engl J Med. 2018. PMID: 30304656 Free article. Clinical Trial.
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