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Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity.
Szczepankiewicz BG, Kosogof C, Nelson LT, Liu G, Liu B, Zhao H, Serby MD, Xin Z, Liu M, Gum RJ, Haasch DL, Wang S, Clampit JE, Johnson EF, Lubben TH, Stashko MA, Olejniczak ET, Sun C, Dorwin SA, Haskins K, Abad-Zapatero C, Fry EH, Hutchins CW, Sham HL, Rondinone CM, Trevillyan JM. Szczepankiewicz BG, et al. Among authors: xin z. J Med Chem. 2006 Jun 15;49(12):3563-80. doi: 10.1021/jm060199b. J Med Chem. 2006. PMID: 16759099
Germinal-center kinase-like kinase co-crystal structure reveals a swapped activation loop and C-terminal extension.
Marcotte D, Rushe M, M Arduini R, Lukacs C, Atkins K, Sun X, Little K, Cullivan M, Paramasivam M, Patterson TA, Hesson T, D McKee T, May-Dracka TL, Xin Z, Bertolotti-Ciarlet A, Bhisetti GR, Lyssikatos JP, Silvian LF. Marcotte D, et al. Among authors: xin z. Protein Sci. 2017 Feb;26(2):152-162. doi: 10.1002/pro.3062. Epub 2016 Oct 21. Protein Sci. 2017. PMID: 27727493 Free PMC article.
Investigating small molecules to inhibit germinal center kinase-like kinase (GLK/MAP4K3) upstream of PKCθ phosphorylation: Potential therapy to modulate T cell dependent immunity.
May-Dracka TL, Arduini R, Bertolotti-Ciarlet A, Bhisetti G, Brickelmaier M, Cahir-McFarland E, Enyedy I, Fontenot JD, Hesson T, Little K, Lyssikatos J, Marcotte D, McKee T, Murugan P, Patterson T, Peng H, Rushe M, Silvian L, Spilker K, Wu P, Xin Z, Burkly LC. May-Dracka TL, et al. Among authors: xin z. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1964-1971. doi: 10.1016/j.bmcl.2018.03.032. Epub 2018 Mar 26. Bioorg Med Chem Lett. 2018. PMID: 29636220
Discovery of CNS-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors.
Xin Z, Himmelbauer MK, Jones JH, Enyedy I, Gilfillan R, Hesson T, King K, Marcotte DJ, Murugan P, Santoro JC, Gonzalez-Lopez de Turiso F. Xin Z, et al. ACS Med Chem Lett. 2020 Feb 12;11(4):485-490. doi: 10.1021/acsmedchemlett.9b00611. eCollection 2020 Apr 9. ACS Med Chem Lett. 2020. PMID: 32292554 Free PMC article.
Discovery of Potent Selective Nonzinc Binding Autotaxin Inhibitor BIO-32546.
Ma B, Zhang L, Sun L, Xin Z, Kumaravel G, Marcotte D, Chodaparambil JV, Wang Q, Wehr A, Jing J, Hong VS, Wang T, Huang C, Shao Z, Mi S. Ma B, et al. Among authors: xin z. ACS Med Chem Lett. 2021 Jun 14;12(7):1124-1129. doi: 10.1021/acsmedchemlett.1c00211. eCollection 2021 Jul 8. ACS Med Chem Lett. 2021. PMID: 34267882 Free PMC article.
Discovery of Potent, Selective, and Brain-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors that Modulate Brain Inflammation In Vivo.
Jones JH, Xin Z, Himmelbauer M, Dechantsreiter M, Enyedy I, Hedde J, Fang T, Coomaraswamy J, King KW, Murugan P, Santoro JC, Hesson T, Walther DM, Wei R, Zheng F, Marcotte DJ, Spilker K, Kumar PR, Liu Y, Gilfillan R, Gonzalez-Lopez de Turiso F. Jones JH, et al. Among authors: xin z. J Med Chem. 2021 Oct 28;64(20):15402-15419. doi: 10.1021/acs.jmedchem.1c01458. Epub 2021 Oct 15. J Med Chem. 2021. PMID: 34653340
Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acetyl-CoA carboxylase 2 inhibitors.
Gu YG, Weitzberg M, Clark RF, Xu X, Li Q, Zhang T, Hansen TM, Liu G, Xin Z, Wang X, Wang R, McNally T, Zinker BA, Frevert EU, Camp HS, Beutel BA, Sham HL. Gu YG, et al. Among authors: xin z. J Med Chem. 2006 Jun 29;49(13):3770-3. doi: 10.1021/jm060484v. J Med Chem. 2006. PMID: 16789734
Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors.
Zhao H, Serby MD, Xin Z, Szczepankiewicz BG, Liu M, Kosogof C, Liu B, Nelson LT, Johnson EF, Wang S, Pederson T, Gum RJ, Clampit JE, Haasch DL, Abad-Zapatero C, Fry EH, Rondinone C, Trevillyan JM, Sham HL, Liu G. Zhao H, et al. Among authors: xin z. J Med Chem. 2006 Jul 27;49(15):4455-8. doi: 10.1021/jm060465l. J Med Chem. 2006. PMID: 16854050
1,467 results