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Preclinical Safety Evaluation and Human Dosimetry of [18F]MK-6240, a Novel PET Tracer for Imaging Neurofibrillary Tangles.
Koole M, Lohith TG, Valentine JL, Bennacef I, Declercq R, Reynders T, Riffel K, Celen S, Serdons K, Bormans G, Ferry-Martin S, Laroque P, Walji A, Hostetler ED, Briscoe RJ, de Hoon J, Sur C, Van Laere K, Struyk A. Koole M, et al. Among authors: briscoe rj. Mol Imaging Biol. 2020 Feb;22(1):173-180. doi: 10.1007/s11307-019-01367-w. Mol Imaging Biol. 2020. PMID: 31111397
Cardiovascular monkey telemetry: sensitivity to detect QT interval prolongation.
Chaves AA, Keller WJ, O'Sullivan S, Williams MA, Fitzgerald LE, McPherson HE, Goykhman D, Ward PD, Hoe CM, Mixson L, Briscoe RJ. Chaves AA, et al. Among authors: briscoe rj. J Pharmacol Toxicol Methods. 2006 Sep-Oct;54(2):150-8. doi: 10.1016/j.vascn.2006.03.004. Epub 2006 Mar 27. J Pharmacol Toxicol Methods. 2006. PMID: 16679034
Preclinical pharmacology and pharmacokinetics of CERC-301, a GluN2B-selective N-methyl-D-aspartate receptor antagonist.
Garner R, Gopalakrishnan S, McCauley JA, Bednar RA, Gaul SL, Mosser SD, Kiss L, Lynch JJ, Patel S, Fandozzi C, Lagrutta A, Briscoe R, Liverton NJ, Paterson BM, Vornov JJ, Mazhari R. Garner R, et al. Among authors: briscoe r. Pharmacol Res Perspect. 2015 Dec 23;3(6):e00198. doi: 10.1002/prp2.198. eCollection 2015 Dec. Pharmacol Res Perspect. 2015. PMID: 27022470 Free PMC article. Review.
A highly sensitive canine telemetry model for detection of QT interval prolongation: studies with moxifloxacin, haloperidol and MK-499.
Chaves AA, Zingaro GJ, Yordy MA, Bustard KA, O'Sullivan S, Galijatovic-Idrizbegovic A, Schuck H, Christian DB, Hoe CM, Briscoe RJ. Chaves AA, et al. Among authors: briscoe rj. J Pharmacol Toxicol Methods. 2007 Sep-Oct;56(2):103-14. doi: 10.1016/j.vascn.2007.04.007. Epub 2007 May 24. J Pharmacol Toxicol Methods. 2007. PMID: 17643323
Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone.
Forrest MJ, Bloomfield D, Briscoe RJ, Brown PN, Cumiskey AM, Ehrhart J, Hershey JC, Keller WJ, Ma X, McPherson HE, Messina E, Peterson LB, Sharif-Rodriguez W, Siegl PK, Sinclair PJ, Sparrow CP, Stevenson AS, Sun SY, Tsai C, Vargas H, Walker M 3rd, West SH, White V, Woltmann RF. Forrest MJ, et al. Among authors: briscoe rj. Br J Pharmacol. 2008 Aug;154(7):1465-73. doi: 10.1038/bjp.2008.229. Epub 2008 Jun 9. Br J Pharmacol. 2008. PMID: 18536749 Free PMC article.
Benchmarking safety pharmacology regulatory packages and best practice.
Lindgren S, Bass AS, Briscoe R, Bruse K, Friedrichs GS, Kallman MJ, Markgraf C, Patmore L, Pugsley MK. Lindgren S, et al. Among authors: briscoe r. J Pharmacol Toxicol Methods. 2008 Sep-Oct;58(2):99-109. doi: 10.1016/j.vascn.2008.07.001. Epub 2008 Jul 19. J Pharmacol Toxicol Methods. 2008. PMID: 18692579
56 results