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Comprehensive AAV capsid fitness landscape reveals a viral gene and enables machine-guided design.
Science. 2019 Nov 29;366(6469):1139-1143. doi: 10.1126/science.aaw2900.
Science. 2019.
PMID: 31780559
Free PMC article.
Deep diversification of an AAV capsid protein by machine learning.
Bryant DH, Bashir A, Sinai S, Jain NK, Ogden PJ, Riley PF, Church GM, Colwell LJ, Kelsic ED.
Bryant DH, et al. Among authors: ogden pj.
Nat Biotechnol. 2021 Jun;39(6):691-696. doi: 10.1038/s41587-020-00793-4. Epub 2021 Feb 11.
Nat Biotechnol. 2021.
PMID: 33574611
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Comprehensive mutagenesis maps the effect of all single-codon mutations in the AAV2 rep gene on AAV production.
Jain NK, Ogden PJ, Church GM.
Jain NK, et al. Among authors: ogden pj.
Elife. 2024 Mar 27;12:RP87730. doi: 10.7554/eLife.87730.
Elife. 2024.
PMID: 38536879
Free PMC article.
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