Schafer P - Search Results

1

Apremilast mechanism of efficacy in systemic-naive patients with moderate plaque psoriasis: Pharmacodynamic results from the UNVEIL study.

Strober B, Alikhan A, Lockshin B, Shi R, Cirulli J, Schafer P. Strober B, et al. Among authors: schafer p. J Dermatol Sci. 2019 Dec;96(3):126-133. doi: 10.1016/j.jdermsci.2019.09.003. Epub 2019 Sep 10. J Dermatol Sci. 2019. PMID: 31787506 Free article. Clinical Trial.

2

Pharmacodynamic analysis of apremilast in Japanese patients with moderate to severe psoriasis: Results from a phase 2b randomized trial.

Imafuku S, Nemoto O, Okubo Y, Komine M, Schafer P, Petric R, Ohtsuki M. Imafuku S, et al. Among authors: schafer p. J Dermatol. 2021 Jan;48(1):80-84. doi: 10.1111/1346-8138.15596. Epub 2020 Sep 10. J Dermatol. 2021. PMID: 32909643 Free PMC article. Clinical Trial.

3

The pharmacodynamic impact of apremilast, an oral phosphodiesterase 4 inhibitor, on circulating levels of inflammatory biomarkers in patients with psoriatic arthritis: substudy results from a phase III, randomized, placebo-controlled trial (PALACE 1).

Schafer PH, Chen P, Fang L, Wang A, Chopra R. Schafer PH, et al. J Immunol Res. 2015;2015:906349. doi: 10.1155/2015/906349. Epub 2015 Apr 20. J Immunol Res. 2015. PMID: 25973439 Free PMC article. Clinical Trial.

4

Synergistic cytokine effects as apremilast response predictors in patients with psoriasis.

Garcet S, Nograles K, Correa da Rosa J, Schafer PH, Krueger JG. Garcet S, et al. J Allergy Clin Immunol. 2018 Sep;142(3):1010-1013.e6. doi: 10.1016/j.jaci.2018.05.039. Epub 2018 Jun 21. J Allergy Clin Immunol. 2018. PMID: 29936103 No abstract available.

5

Large-scale Analyses of Disease Biomarkers and Apremilast Pharmacodynamic Effects.

Medvedeva IV, Stokes ME, Eisinger D, LaBrie ST, Ai J, Trotter MWB, Schafer P, Yang R. Medvedeva IV, et al. Among authors: schafer p. Sci Rep. 2020 Jan 17;10(1):605. doi: 10.1038/s41598-020-57542-5. Sci Rep. 2020. PMID: 31953524 Free PMC article. Clinical Trial.

6

Apremilast mechanism of action and application to psoriasis and psoriatic arthritis.

Schafer P. Schafer P. Biochem Pharmacol. 2012 Jun 15;83(12):1583-90. doi: 10.1016/j.bcp.2012.01.001. Epub 2012 Jan 10. Biochem Pharmacol. 2012. PMID: 22257911

7

Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis.

Schafer PH, Parton A, Gandhi AK, Capone L, Adams M, Wu L, Bartlett JB, Loveland MA, Gilhar A, Cheung YF, Baillie GS, Houslay MD, Man HW, Muller GW, Stirling DI. Schafer PH, et al. Br J Pharmacol. 2010 Feb;159(4):842-55. doi: 10.1111/j.1476-5381.2009.00559.x. Epub 2009 Dec 24. Br J Pharmacol. 2010. PMID: 20050849 Free PMC article.

8

Apremilast Normalizes Gene Expression of Inflammatory Mediators in Human Keratinocytes and Reduces Antigen-Induced Atopic Dermatitis in Mice.

Schafer PH, Adams M, Horan G, Truzzi F, Marconi A, Pincelli C. Schafer PH, et al. Drugs R D. 2019 Dec;19(4):329-338. doi: 10.1007/s40268-019-00284-1. Drugs R D. 2019. PMID: 31598889 Free PMC article.

9

Phosphodiesterase 4 in inflammatory diseases: Effects of apremilast in psoriatic blood and in dermal myofibroblasts through the PDE4/CD271 complex.

Schafer PH, Truzzi F, Parton A, Wu L, Kosek J, Zhang LH, Horan G, Saltari A, Quadri M, Lotti R, Marconi A, Pincelli C. Schafer PH, et al. Cell Signal. 2016 Jul;28(7):753-63. doi: 10.1016/j.cellsig.2016.01.007. Epub 2016 Jan 22. Cell Signal. 2016. PMID: 26806620 Free article.

10

Efficacy, tolerability, and pharmacodynamics of apremilast in recalcitrant plaque psoriasis: a phase II open-label study.

Gottlieb AB, Matheson RT, Menter A, Leonardi CL, Day RM, Hu C, Schafer PH, Krueger JG. Gottlieb AB, et al. J Drugs Dermatol. 2013 Aug;12(8):888-97. J Drugs Dermatol. 2013. PMID: 23986162 Clinical Trial.

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