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Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation.
Speir M, Nowell CJ, Chen AA, O'Donnell JA, Shamie IS, Lakin PR, D'Cruz AA, Braun RO, Babon JJ, Lewis RS, Bliss-Moreau M, Shlomovitz I, Wang S, Cengia LH, Stoica AI, Hakem R, Kelliher MA, O'Reilly LA, Patsiouras H, Lawlor KE, Weller E, Lewis NE, Roberts AW, Gerlic M, Croker BA. Speir M, et al. Among authors: lewis rs, lewis ne. Nat Immunol. 2020 Jan;21(1):54-64. doi: 10.1038/s41590-019-0550-7. Epub 2019 Dec 9. Nat Immunol. 2020. PMID: 31819256 Free PMC article.
Reduced apoptosis in Chinese hamster ovary cells via optimized CRISPR interference.
Xiong K, Marquart KF, la Cour Karottki KJ, Li S, Shamie I, Lee JS, Gerling S, Yeo NC, Chavez A, Lee GM, Lewis NE, Kildegaard HF. Xiong K, et al. Among authors: lewis ne. Biotechnol Bioeng. 2019 Jul;116(7):1813-1819. doi: 10.1002/bit.26969. Epub 2019 Apr 2. Biotechnol Bioeng. 2019. PMID: 30883679 Free PMC article.
Awakening dormant glycosyltransferases in CHO cells with CRISPRa.
Karottki KJC, Hefzi H, Xiong K, Shamie I, Hansen AH, Li S, Pedersen LE, Li S, Lee JS, Lee GM, Kildegaard HF, Lewis NE. Karottki KJC, et al. Among authors: lewis ne. Biotechnol Bioeng. 2020 Feb;117(2):593-598. doi: 10.1002/bit.27199. Epub 2019 Nov 12. Biotechnol Bioeng. 2020. PMID: 31631317 Free PMC article.
A Chinese hamster transcription start site atlas that enables targeted editing of CHO cells.
Shamie I, Duttke SH, Karottki KJC, Han CZ, Hansen AH, Hefzi H, Xiong K, Li S, Roth SJ, Tao J, Lee GM, Glass CK, Kildegaard HF, Benner C, Lewis NE. Shamie I, et al. Among authors: lewis ne. NAR Genom Bioinform. 2021 Jul 13;3(3):lqab061. doi: 10.1093/nargab/lqab061. eCollection 2021 Sep. NAR Genom Bioinform. 2021. PMID: 34268494 Free PMC article.
Immune response to intravenous immunoglobulin in patients with Kawasaki disease and MIS-C.
Zhu YP, Shamie I, Lee JC, Nowell CJ, Peng W, Angulo S, Le LN, Liu Y, Miao H, Xiong H, Pena CJ, Moreno E, Griffis E, Labou SG, Franco A, Broderick L, Hoffman HM, Shimizu C, Lewis NE, Kanegaye JT, Tremoulet AH, Burns JC, Croker BA; Pediatric Emergency Medicine Kawasaki Disease Research Group Consortium. Zhu YP, et al. Among authors: lewis ne. J Clin Invest. 2021 Oct 15;131(20):e147076. doi: 10.1172/JCI147076. J Clin Invest. 2021. PMID: 34464357 Free PMC article.
Inferring a spatial code of cell-cell interactions across a whole animal body.
Armingol E, Ghaddar A, Joshi CJ, Baghdassarian H, Shamie I, Chan J, Her HL, Berhanu S, Dar A, Rodriguez-Armstrong F, Yang O, O'Rourke EJ, Lewis NE. Armingol E, et al. Among authors: lewis ne. PLoS Comput Biol. 2022 Nov 17;18(11):e1010715. doi: 10.1371/journal.pcbi.1010715. eCollection 2022 Nov. PLoS Comput Biol. 2022. PMID: 36395331 Free PMC article.
Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.
Shen JP, Zhao D, Sasik R, Luebeck J, Birmingham A, Bojorquez-Gomez A, Licon K, Klepper K, Pekin D, Beckett AN, Sanchez KS, Thomas A, Kuo CC, Du D, Roguev A, Lewis NE, Chang AN, Kreisberg JF, Krogan N, Qi L, Ideker T, Mali P. Shen JP, et al. Among authors: lewis ne. Nat Methods. 2017 Jun;14(6):573-576. doi: 10.1038/nmeth.4225. Epub 2017 Mar 20. Nat Methods. 2017. PMID: 28319113 Free PMC article.
191 results