La Spada AR - Search Results

1

Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7.

Stoyas CA, Bushart DD, Switonski PM, Ward JM, Alaghatta A, Tang MB, Niu C, Wadhwa M, Huang H, Savchenko A, Gariani K, Xie F, Delaney JR, Gaasterland T, Auwerx J, Shakkottai VG, La Spada AR. Stoyas CA, et al. Among authors: la spada ar. Neuron. 2020 Feb 19;105(4):630-644.e9. doi: 10.1016/j.neuron.2019.11.019. Epub 2019 Dec 16. Neuron. 2020. PMID: 31859031 Free PMC article.

2

Polyglutamine-expanded ataxin-7 antagonizes CRX function and induces cone-rod dystrophy in a mouse model of SCA7.

La Spada AR, Fu YH, Sopher BL, Libby RT, Wang X, Li LY, Einum DD, Huang J, Possin DE, Smith AC, Martinez RA, Koszdin KL, Treuting PM, Ware CB, Hurley JB, Ptácek LJ, Chen S. La Spada AR, et al. Neuron. 2001 Sep 27;31(6):913-27. doi: 10.1016/s0896-6273(01)00422-6. Neuron. 2001. PMID: 11580893 Free article.

3

Polyglutamines placed into context.

La Spada AR, Taylor JP. La Spada AR, et al. Neuron. 2003 Jun 5;38(5):681-4. doi: 10.1016/s0896-6273(03)00328-3. Neuron. 2003. PMID: 12797953 Free article. Review.

4

CTCF regulates ataxin-7 expression through promotion of a convergently transcribed, antisense noncoding RNA.

Sopher BL, Ladd PD, Pineda VV, Libby RT, Sunkin SM, Hurley JB, Thienes CP, Gaasterland T, Filippova GN, La Spada AR. Sopher BL, et al. Among authors: la spada ar. Neuron. 2011 Jun 23;70(6):1071-84. doi: 10.1016/j.neuron.2011.05.027. Neuron. 2011. PMID: 21689595 Free PMC article.

5

The expanding world of stem cell modeling of Huntington's disease: creating tools with a promising future.

Ward JM, La Spada AR. Ward JM, et al. Among authors: la spada ar. Genome Med. 2012 Aug 31;4(8):68. doi: 10.1186/gm369. eCollection 2012. Genome Med. 2012. PMID: 22943447 Free PMC article.

6

Muscle expression of mutant androgen receptor accounts for systemic and motor neuron disease phenotypes in spinal and bulbar muscular atrophy.

Cortes CJ, Ling SC, Guo LT, Hung G, Tsunemi T, Ly L, Tokunaga S, Lopez E, Sopher BL, Bennett CF, Shelton GD, Cleveland DW, La Spada AR. Cortes CJ, et al. Among authors: la spada ar. Neuron. 2014 Apr 16;82(2):295-307. doi: 10.1016/j.neuron.2014.03.001. Neuron. 2014. PMID: 24742458 Free PMC article.

7

RNA interference-based therapy for spinocerebellar ataxia type 7 retinal degeneration.

Ramachandran PS, Bhattarai S, Singh P, Boudreau RL, Thompson S, Laspada AR, Drack AV, Davidson BL. Ramachandran PS, et al. PLoS One. 2014 Apr 23;9(4):e95362. doi: 10.1371/journal.pone.0095362. eCollection 2014. PLoS One. 2014. PMID: 24759684 Free PMC article.

8

Identification of the SCA21 disease gene: remaining challenges and promising opportunities.

Ward JM, La Spada AR. Ward JM, et al. Among authors: la spada ar. Brain. 2014 Oct;137(Pt 10):2626-8. doi: 10.1093/brain/awu217. Brain. 2014. PMID: 25217789 Free PMC article.

9

Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy.

Dubinsky AN, Dastidar SG, Hsu CL, Zahra R, Djakovic SN, Duarte S, Esau CC, Spencer B, Ashe TD, Fischer KM, MacKenna DA, Sopher BL, Masliah E, Gaasterland T, Chau BN, Pereira de Almeida L, Morrison BE, La Spada AR. Dubinsky AN, et al. Among authors: la spada ar. Cell Metab. 2014 Oct 7;20(4):626-38. doi: 10.1016/j.cmet.2014.09.001. Cell Metab. 2014. PMID: 25295787 Free PMC article.

10

Ataxin-3, DNA damage repair, and SCA3 cerebellar degeneration: on the path to parsimony?

Ward JM, La Spada AR. Ward JM, et al. Among authors: la spada ar. PLoS Genet. 2015 Jan 29;11(1):e1004937. doi: 10.1371/journal.pgen.1004937. eCollection 2015 Jan. PLoS Genet. 2015. PMID: 25633989 Free PMC article. No abstract available.

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