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Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer.
Proc Natl Acad Sci U S A. 2020 Jan 14;117(2):1119-1128. doi: 10.1073/pnas.1904022116. Epub 2019 Dec 30.
Proc Natl Acad Sci U S A. 2020.
PMID: 31888983
Free PMC article.
MEK inhibition enhances oncolytic virus immunotherapy through increased tumor cell killing and T cell activation.
Bommareddy PK, Aspromonte S, Zloza A, Rabkin SD, Kaufman HL.
Bommareddy PK, et al.
Sci Transl Med. 2018 Dec 12;10(471):eaau0417. doi: 10.1126/scitranslmed.aau0417.
Sci Transl Med. 2018.
PMID: 30541787
Free PMC article.
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Safety and enhanced immunostimulatory activity of the DRD2 antagonist ONC201 in advanced solid tumor patients with weekly oral administration.
Stein MN, Malhotra J, Tarapore RS, Malhotra U, Silk AW, Chan N, Rodriguez L, Aisner J, Aiken RD, Mayer T, Haffty BG, Newman JH, Aspromonte SM, Bommareddy PK, Estupinian R, Chesson CB, Sadimin ET, Li S, Medina DJ, Saunders T, Frankel M, Kareddula A, Damare S, Wesolowsky E, Gabel C, El-Deiry WS, Prabhu VV, Allen JE, Stogniew M, Oster W, Bertino JR, Libutti SK, Mehnert JM, Zloza A.
Stein MN, et al. Among authors: aspromonte sm.
J Immunother Cancer. 2019 May 22;7(1):136. doi: 10.1186/s40425-019-0599-8.
J Immunother Cancer. 2019.
PMID: 31118108
Free PMC article.
Clinical Trial.
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Gut Microbial Shifts Indicate Melanoma Presence and Bacterial Interactions in a Murine Model.
Rossi M, Aspromonte SM, Kohlhapp FJ, Newman JH, Lemenze A, Pepe RJ, DeFina SM, Herzog NL, Donnelly R, Kuzel TM, Reiser J, Guevara-Patino JA, Zloza A.
Rossi M, et al. Among authors: aspromonte sm.
Diagnostics (Basel). 2022 Apr 12;12(4):958. doi: 10.3390/diagnostics12040958.
Diagnostics (Basel). 2022.
PMID: 35454006
Free PMC article.
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