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Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer.
Newman JH, Chesson CB, Herzog NL, Bommareddy PK, Aspromonte SM, Pepe R, Estupinian R, Aboelatta MM, Buddhadev S, Tarabichi S, Lee M, Li S, Medina DJ, Giurini EF, Gupta KH, Guevara-Aleman G, Rossi M, Nowicki C, Abed A, Goldufsky JW, Broucek JR, Redondo RE, Rotter D, Jhawar SR, Wang SJ, Kohlhapp FJ, Kaufman HL, Thomas PG, Gupta V, Kuzel TM, Reiser J, Paras J, Kane MP, Singer EA, Malhotra J, Denzin LK, Sant'Angelo DB, Rabson AB, Lee LY, Lasfar A, Langenfeld J, Schenkel JM, Fidler MJ, Ruiz ES, Marzo AL, Rudra JS, Silk AW, Zloza A. Newman JH, et al. Among authors: thomas pg. Proc Natl Acad Sci U S A. 2020 Jan 14;117(2):1119-1128. doi: 10.1073/pnas.1904022116. Epub 2019 Dec 30. Proc Natl Acad Sci U S A. 2020. PMID: 31888983 Free PMC article.
Contemporary seasonal influenza A (H1N1) virus infection primes for a more robust response to split inactivated pandemic influenza A (H1N1) Virus vaccination in ferrets.
Ellebedy AH, Fabrizio TP, Kayali G, Oguin TH 3rd, Brown SA, Rehg J, Thomas PG, Webby RJ. Ellebedy AH, et al. Among authors: thomas pg. Clin Vaccine Immunol. 2010 Dec;17(12):1998-2006. doi: 10.1128/CVI.00247-10. Epub 2010 Oct 20. Clin Vaccine Immunol. 2010. PMID: 20962210 Free PMC article.
T cell immunoglobulin and mucin protein-3 (Tim-3)/Galectin-9 interaction regulates influenza A virus-specific humoral and CD8 T-cell responses.
Sharma S, Sundararajan A, Suryawanshi A, Kumar N, Veiga-Parga T, Kuchroo VK, Thomas PG, Sangster MY, Rouse BT. Sharma S, et al. Among authors: thomas pg. Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):19001-6. doi: 10.1073/pnas.1107087108. Epub 2011 Nov 3. Proc Natl Acad Sci U S A. 2011. PMID: 22052881 Free PMC article.
NKG2D signaling on CD8⁺ T cells represses T-bet and rescues CD4-unhelped CD8⁺ T cell memory recall but not effector responses.
Zloza A, Kohlhapp FJ, Lyons GE, Schenkel JM, Moore TV, Lacek AT, O'Sullivan JA, Varanasi V, Williams JW, Jagoda MC, Bellavance EC, Marzo AL, Thomas PG, Zafirova B, Polić B, Al-Harthi L, Sperling AI, Guevara-Patiño JA. Zloza A, et al. Among authors: thomas pg. Nat Med. 2012 Feb 26;18(3):422-8. doi: 10.1038/nm.2683. Nat Med. 2012. PMID: 22366950 Free PMC article.
Heightened self-reactivity associated with selective survival, but not expansion, of naïve virus-specific CD8+ T cells in aged mice.
Quinn KM, Zaloumis SG, Cukalac T, Kan WT, Sng XY, Mirams M, Watson KA, McCaw JM, Doherty PC, Thomas PG, Handel A, La Gruta NL. Quinn KM, et al. Among authors: thomas pg. Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1333-8. doi: 10.1073/pnas.1525167113. Epub 2016 Jan 19. Proc Natl Acad Sci U S A. 2016. PMID: 26787864 Free PMC article.
Molecular basis for universal HLA-A*0201-restricted CD8+ T-cell immunity against influenza viruses.
Valkenburg SA, Josephs TM, Clemens EB, Grant EJ, Nguyen TH, Wang GC, Price DA, Miller A, Tong SY, Thomas PG, Doherty PC, Rossjohn J, Gras S, Kedzierska K. Valkenburg SA, et al. Among authors: thomas pg. Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4440-5. doi: 10.1073/pnas.1603106113. Epub 2016 Mar 31. Proc Natl Acad Sci U S A. 2016. PMID: 27036003 Free PMC article. Clinical Trial.
Non-oncogenic Acute Viral Infections Disrupt Anti-cancer Responses and Lead to Accelerated Cancer-Specific Host Death.
Kohlhapp FJ, Huelsmann EJ, Lacek AT, Schenkel JM, Lusciks J, Broucek JR, Goldufsky JW, Hughes T, Zayas JP, Dolubizno H, Sowell RT, Kühner R, Burd S, Kubasiak JC, Nabatiyan A, Marshall S, Bommareddy PK, Li S, Newman JH, Monken CE, Shafikhani SH, Marzo AL, Guevara-Patino JA, Lasfar A, Thomas PG, Lattime EC, Kaufman HL, Zloza A. Kohlhapp FJ, et al. Among authors: thomas pg. Cell Rep. 2016 Oct 18;17(4):957-965. doi: 10.1016/j.celrep.2016.09.068. Cell Rep. 2016. PMID: 27760326 Free PMC article.
364 results