Chen B - Search Results

1

Harnessing big 'omics' data and AI for drug discovery in hepatocellular carcinoma.

Chen B, Garmire L, Calvisi DF, Chua MS, Kelley RK, Chen X. Chen B, et al. Among authors: chen x. Nat Rev Gastroenterol Hepatol. 2020 Apr;17(4):238-251. doi: 10.1038/s41575-019-0240-9. Epub 2020 Jan 3. Nat Rev Gastroenterol Hepatol. 2020. PMID: 31900465 Free PMC article. Review.

2

Leveraging big data to transform target selection and drug discovery.

Chen B, Butte AJ. Chen B, et al. Clin Pharmacol Ther. 2016 Mar;99(3):285-97. doi: 10.1002/cpt.318. Clin Pharmacol Ther. 2016. PMID: 26659699 Free PMC article. Review.

3

Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling.

Chen B, Wei W, Ma L, Yang B, Gill RM, Chua MS, Butte AJ, So S. Chen B, et al. Gastroenterology. 2017 Jun;152(8):2022-2036. doi: 10.1053/j.gastro.2017.02.039. Epub 2017 Mar 8. Gastroenterology. 2017. PMID: 28284560 Free PMC article.

4

Reversal of cancer gene expression correlates with drug efficacy and reveals therapeutic targets.

Chen B, Ma L, Paik H, Sirota M, Wei W, Chua MS, So S, Butte AJ. Chen B, et al. Nat Commun. 2017 Jul 12;8:16022. doi: 10.1038/ncomms16022. Nat Commun. 2017. PMID: 28699633 Free PMC article.

5

Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma in mice.

Zhang S, Song X, Cao D, Xu Z, Fan B, Che L, Hu J, Chen B, Dong M, Pilo MG, Cigliano A, Evert K, Ribback S, Dombrowski F, Pascale RM, Cossu A, Vidili G, Porcu A, Simile MM, Pes GM, Giannelli G, Gordan J, Wei L, Evert M, Cong W, Calvisi DF, Chen X. Zhang S, et al. Among authors: chen b, chen x. J Hepatol. 2017 Dec;67(6):1194-1203. doi: 10.1016/j.jhep.2017.07.006. Epub 2017 Jul 19. J Hepatol. 2017. PMID: 28733220 Free PMC article.

6

Hippo Cascade Controls Lineage Commitment of Liver Tumors in Mice and Humans.

Zhang S, Wang J, Wang H, Fan L, Fan B, Zeng B, Tao J, Li X, Che L, Cigliano A, Ribback S, Dombrowski F, Chen B, Cong W, Wei L, Calvisi DF, Chen X. Zhang S, et al. Among authors: chen b, chen x. Am J Pathol. 2018 Apr;188(4):995-1006. doi: 10.1016/j.ajpath.2017.12.017. Epub 2018 Jan 31. Am J Pathol. 2018. PMID: 29378174 Free PMC article.

7

Leveraging Big Data to Transform Drug Discovery.

Glicksberg BS, Li L, Chen R, Dudley J, Chen B. Glicksberg BS, et al. Among authors: chen r, chen b. Methods Mol Biol. 2019;1939:91-118. doi: 10.1007/978-1-4939-9089-4_6. Methods Mol Biol. 2019. PMID: 30848458 Free PMC article.

8

Evaluating cell lines as models for metastatic breast cancer through integrative analysis of genomic data.

Liu K, Newbury PA, Glicksberg BS, Zeng WZD, Paithankar S, Andrechek ER, Chen B. Liu K, et al. Among authors: chen b. Nat Commun. 2019 May 15;10(1):2138. doi: 10.1038/s41467-019-10148-6. Nat Commun. 2019. PMID: 31092827 Free PMC article.

9

A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS.

McMahon M, Contreras A, Holm M, Uechi T, Forester CM, Pang X, Jackson C, Calvert ME, Chen B, Quigley DA, Luk JM, Kelley RK, Gordan JD, Gill RM, Blanchard SC, Ruggero D. McMahon M, et al. Among authors: chen b. Elife. 2019 Sep 3;8:e48847. doi: 10.7554/eLife.48847. Elife. 2019. PMID: 31478838 Free PMC article.

10

Publisher Correction: Harnessing big 'omics' data and AI for drug discovery in hepatocellular carcinoma.

Chen B, Garmire L, Calvisi DF, Chua MS, Kelley RK, Chen X. Chen B, et al. Among authors: chen x. Nat Rev Gastroenterol Hepatol. 2020 Mar 11:10.1038/s41575-020-0288-6. doi: 10.1038/s41575-020-0288-6. Online ahead of print. Nat Rev Gastroenterol Hepatol. 2020. PMID: 32161375 Free PMC article. No abstract available.

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