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Structural insights and activating mutations in diverse pathologies define mechanisms of deregulation for phospholipase C gamma enzymes.
Liu Y, Bunney TD, Khosa S, Macé K, Beckenbauer K, Askwith T, Maslen S, Stubbs C, de Oliveira TM, Sader K, Skehel M, Gavin AC, Phillips C, Katan M. Liu Y, et al. Among authors: stubbs c. EBioMedicine. 2020 Jan;51:102607. doi: 10.1016/j.ebiom.2019.102607. Epub 2020 Jan 6. EBioMedicine. 2020. PMID: 31918402 Free PMC article.
KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe.
Bery N, Legg S, Debreczeni J, Breed J, Embrey K, Stubbs C, Kolasinska-Zwierz P, Barrett N, Marwood R, Watson J, Tart J, Overman R, Miller A, Phillips C, Minter R, Rabbitts TH. Bery N, et al. Among authors: stubbs c. Nat Commun. 2019 Jun 13;10(1):2607. doi: 10.1038/s41467-019-10419-2. Nat Commun. 2019. PMID: 31197133 Free PMC article.
Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Collie GW, Michaelides IN, Embrey K, Stubbs CJ, Börjesson U, Dale IL, Snijder A, Barlind L, Song K, Khurana P, Phillips C, Storer RI. Collie GW, et al. Among authors: stubbs cj. ACS Med Chem Lett. 2020 Dec 8;12(1):162-167. doi: 10.1021/acsmedchemlett.0c00392. eCollection 2021 Jan 14. ACS Med Chem Lett. 2020. PMID: 33488978 Free PMC article.
Structural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors.
Collie GW, Koh CM, O'Neill DJ, Stubbs CJ, Khurana P, Eddershaw A, Snijder A, Mauritzson F, Barlind L, Dale IL, Shaw J, Phillips C, Hennessy EJ, Cheung T, Narvaez AJ. Collie GW, et al. Among authors: stubbs cj. ACS Med Chem Lett. 2019 Aug 2;10(9):1322-1327. doi: 10.1021/acsmedchemlett.9b00276. eCollection 2019 Sep 12. ACS Med Chem Lett. 2019. PMID: 31531204 Free PMC article.
Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor.
Michaelides IN, Collie GW, Börjesson U, Vasalou C, Alkhatib O, Barlind L, Cheung T, Dale IL, Embrey KJ, Hennessy EJ, Khurana P, Koh CM, Lamb ML, Liu J, Moss TA, O'Neill DJ, Phillips C, Shaw J, Snijder A, Storer RI, Stubbs CJ, Han F, Li C, Qiao J, Sun DQ, Wang J, Wang P, Yang W. Michaelides IN, et al. Among authors: stubbs cj. J Med Chem. 2023 Jul 13;66(13):8782-8807. doi: 10.1021/acs.jmedchem.3c00401. Epub 2023 Jun 21. J Med Chem. 2023. PMID: 37343272 Free PMC article.
249 results