O'Donoghue AJ - Search Results

1

Tutuilamides A-C: Vinyl-Chloride-Containing Cyclodepsipeptides from Marine Cyanobacteria with Potent Elastase Inhibitory Properties.

Keller L, Canuto KM, Liu C, Suzuki BM, Almaliti J, Sikandar A, Naman CB, Glukhov E, Luo D, Duggan BM, Luesch H, Koehnke J, O'Donoghue AJ, Gerwick WH. Keller L, et al. ACS Chem Biol. 2020 Mar 20;15(3):751-757. doi: 10.1021/acschembio.9b00992. Epub 2020 Jan 28. ACS Chem Biol. 2020. PMID: 31935054 Free PMC article.

2

Excretion/secretion products from Schistosoma mansoni adults, eggs and schistosomula have unique peptidase specificity profiles.

Dvořák J, Fajtová P, Ulrychová L, Leontovyč A, Rojo-Arreola L, Suzuki BM, Horn M, Mareš M, Craik CS, Caffrey CR, O'Donoghue AJ. Dvořák J, et al. Biochimie. 2016 Mar;122:99-109. doi: 10.1016/j.biochi.2015.09.025. Epub 2015 Sep 26. Biochimie. 2016. PMID: 26409899 Free PMC article.

3

Cysteine and Aspartyl Proteases Contribute to Protein Digestion in the Gut of Freshwater Planaria.

Goupil LS, Ivry SL, Hsieh I, Suzuki BM, Craik CS, O'Donoghue AJ, McKerrow JH. Goupil LS, et al. PLoS Negl Trop Dis. 2016 Aug 8;10(8):e0004893. doi: 10.1371/journal.pntd.0004893. eCollection 2016 Aug. PLoS Negl Trop Dis. 2016. PMID: 27501047 Free PMC article.

4

Substrate Profiling and High Resolution Co-complex Crystal Structure of a Secreted C11 Protease Conserved across Commensal Bacteria.

Roncase EJ, Moon C, Chatterjee S, González-Páez GE, Craik CS, O'Donoghue AJ, Wolan DW. Roncase EJ, et al. ACS Chem Biol. 2017 Jun 16;12(6):1556-1565. doi: 10.1021/acschembio.7b00143. Epub 2017 Apr 27. ACS Chem Biol. 2017. PMID: 28414448 Free PMC article.

5

Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity.

LaMonte GM, Almaliti J, Bibo-Verdugo B, Keller L, Zou BY, Yang J, Antonova-Koch Y, Orjuela-Sanchez P, Boyle CA, Vigil E, Wang L, Goldgof GM, Gerwick L, O'Donoghue AJ, Winzeler EA, Gerwick WH, Ottilie S. LaMonte GM, et al. J Med Chem. 2017 Aug 10;60(15):6721-6732. doi: 10.1021/acs.jmedchem.7b00671. Epub 2017 Jul 25. J Med Chem. 2017. PMID: 28696697 Free PMC article.

6

A Commensal Dipeptidyl Aminopeptidase with Specificity for N-Terminal Glycine Degrades Human-Produced Antimicrobial Peptides in Vitro.

Xu JH, Jiang Z, Solania A, Chatterjee S, Suzuki B, Lietz CB, Hook VYH, O'Donoghue AJ, Wolan DW. Xu JH, et al. ACS Chem Biol. 2018 Sep 21;13(9):2513-2521. doi: 10.1021/acschembio.8b00420. Epub 2018 Aug 23. ACS Chem Biol. 2018. PMID: 30085657 Free PMC article.

7

Characterization of PdCP1, a serine carboxypeptidase from Pseudogymnoascus destructans, the causal agent of White-nose Syndrome.

Beekman C, Jiang Z, Suzuki BM, Palmer JM, Lindner DL, O'Donoghue AJ, Knudsen GM, Bennett RJ. Beekman C, et al. Biol Chem. 2018 Nov 27;399(12):1375-1388. doi: 10.1515/hsz-2018-0240. Biol Chem. 2018. PMID: 30367778

8

The Proteasome as a Drug Target in the Metazoan Pathogen, Schistosoma mansoni.

Bibo-Verdugo B, Wang SC, Almaliti J, Ta AP, Jiang Z, Wong DA, Lietz CB, Suzuki BM, El-Sakkary N, Hook V, Salvesen GS, Gerwick WH, Caffrey CR, O'Donoghue AJ. Bibo-Verdugo B, et al. ACS Infect Dis. 2019 Oct 11;5(10):1802-1812. doi: 10.1021/acsinfecdis.9b00237. Epub 2019 Aug 12. ACS Infect Dis. 2019. PMID: 31355632 Free PMC article.

9

20S Proteasome as a Drug Target in Trichomonas vaginalis.

O'Donoghue AJ, Bibo-Verdugo B, Miyamoto Y, Wang SC, Yang JZ, Zuill DE, Matsuka S, Jiang Z, Almaliti J, Caffrey CR, Gerwick WH, Eckmann L. O'Donoghue AJ, et al. Antimicrob Agents Chemother. 2019 Oct 22;63(11):e00448-19. doi: 10.1128/AAC.00448-19. Print 2019 Nov. Antimicrob Agents Chemother. 2019. PMID: 31451503 Free PMC article.

10

A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells.

Mellott DM, Tseng CT, Drelich A, Fajtová P, Chenna BC, Kostomiris DH, Hsu J, Zhu J, Taylor ZW, Kocurek KI, Tat V, Katzfuss A, Li L, Giardini MA, Skinner D, Hirata K, Yoon MC, Beck S, Carlin AF, Clark AE, Beretta L, Maneval D, Hook V, Frueh F, Hurst BL, Wang H, Raushel FM, O'Donoghue AJ, de Siqueira-Neto JL, Meek TD, McKerrow JH. Mellott DM, et al. ACS Chem Biol. 2021 Apr 16;16(4):642-650. doi: 10.1021/acschembio.0c00875. Epub 2021 Mar 31. ACS Chem Biol. 2021. PMID: 33787221

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