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Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance.
Grünberg JR, Hoffmann JM, Hedjazifar S, Nerstedt A, Jenndahl L, Elvin J, Castellot J, Wei L, Movérare-Skrtic S, Ohlsson C, Holm LM, Bäckhed F, Syed I, Bosch F, Saghatelian A, Kahn BB, Hammarstedt A, Smith U. Grünberg JR, et al. Among authors: bosch f. Sci Rep. 2017 Feb 27;7:43515. doi: 10.1038/srep43515. Sci Rep. 2017. PMID: 28240264 Free PMC article.
Adult mice are unresponsive to AAV8-Gremlin1 gene therapy targeting the liver.
Khatib Shahidi R, M Hoffmann J, Hedjazifar S, Bonnet L, K Baboota R, Heasman S, Church C, Elias I, Bosch F, Boucher J, Hammarstedt A, Smith U. Khatib Shahidi R, et al. Among authors: bosch f. PLoS One. 2021 Feb 19;16(2):e0247300. doi: 10.1371/journal.pone.0247300. eCollection 2021. PLoS One. 2021. PMID: 33606810 Free PMC article.
FGF21 gene therapy as treatment for obesity and insulin resistance.
Jimenez V, Jambrina C, Casana E, Sacristan V, Muñoz S, Darriba S, Rodó J, Mallol C, Garcia M, León X, Marcó S, Ribera A, Elias I, Casellas A, Grass I, Elias G, Ferré T, Motas S, Franckhauser S, Mulero F, Navarro M, Haurigot V, Ruberte J, Bosch F. Jimenez V, et al. Among authors: bosch f. EMBO Mol Med. 2018 Aug;10(8):e8791. doi: 10.15252/emmm.201708791. EMBO Mol Med. 2018. PMID: 29987000 Free PMC article.
AAV-mediated BMP7 gene therapy counteracts insulin resistance and obesity.
Casana E, Jimenez V, Jambrina C, Sacristan V, Muñoz S, Rodo J, Grass I, Garcia M, Mallol C, León X, Casellas A, Sánchez V, Franckhauser S, Ferré T, Marcó S, Bosch F. Casana E, et al. Among authors: bosch f. Mol Ther Methods Clin Dev. 2022 Mar 16;25:190-204. doi: 10.1016/j.omtm.2022.03.007. eCollection 2022 Jun 9. Mol Ther Methods Clin Dev. 2022. PMID: 35434177 Free PMC article.
Treatment of diabetes and long-term survival after insulin and glucokinase gene therapy.
Callejas D, Mann CJ, Ayuso E, Lage R, Grifoll I, Roca C, Andaluz A, Ruiz-de Gopegui R, Montané J, Muñoz S, Ferre T, Haurigot V, Zhou S, Ruberte J, Mingozzi F, High KA, Garcia F, Bosch F. Callejas D, et al. Among authors: bosch f. Diabetes. 2013 May;62(5):1718-29. doi: 10.2337/db12-1113. Epub 2013 Feb 1. Diabetes. 2013. PMID: 23378612 Free PMC article.
1,493 results